Accelerated long-term forgetting in temporal lobe epilepsy: Evidence of improvement after left temporal pole lobectomy

Roberto Gallassi, Luisa Sambati, Roberto Poda, Michelangelo Stanzani Maserati, Federico Oppi, Marco Giulioni, Paolo Tinuper

Research output: Contribution to journalArticlepeer-review

Abstract

Accelerated long term forgetting (ALF) is a characteristic cognitive aspect in patients affected by temporal lobe epilepsy that is probably due to an impairment of memory consolidation and retrieval caused by epileptic activity in hippocampal and parahippocampal regions. We describe a case of a patient with TLE who showed improvement in ALF and in remote memory impairment after an anterior left temporal pole lobectomy including the uncus and amygdala. Our findings confirm that impairment of hippocampal functioning leads to pathological ALF, whereas restoration of hippocampal functioning brings ALF to a level comparable to that of controls.

Original languageEnglish
Pages (from-to)793-795
Number of pages3
JournalEpilepsy and Behavior
Volume22
Issue number4
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Accelerated long-term forgetting
  • Amnesia
  • Cognitive functions
  • Memory
  • Neuropsychology
  • Temporal lobe epilepsy
  • Temporal pole lobectomy

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

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