Access denied? The status of co-receptor inhibition to counter HIV entry

Priscilla Biswas, Giuseppe Tambussi, Adriano Lazzarin

Research output: Contribution to journalArticle

Abstract

As resistance and long-term metabolic abnormalities hamper the efficacy of previous drugs against HIV-1, targeting of HIV co-receptors represents an exciting new frontier for antiretroviral therapeutics. CCR5 inhibitors are most likely to be the new available drugs within the class of entry inhibitors. This paper reviews the most recent clinical data available on the small-molecule compounds vicriviroc and maraviroc and on the antibodies PRO 140 and CCR5mAb004, as well as some novel genetic approaches. A thorough overview of the many challenges, past, present and future, that CCR5 inhibitors encounter during their development pathway is then presented. Possible immunologic consequences are also discussed. It could be foreseen that the benefit for HIV-infected individuals derived by the use of these potential novel drugs will outweigh the costs/risks intrinsically present in every new therapeutic approach.

Original languageEnglish
Pages (from-to)923-933
Number of pages11
JournalExpert Opinion on Pharmacotherapy
Volume8
Issue number7
DOIs
Publication statusPublished - May 2007

Keywords

  • Antiretroviral
  • CCL3
  • CCL4
  • CCL5
  • CCR5 inhibitor
  • CCR5-tropic
  • CCR5mAb004
  • CXCR4-tropic
  • Entry inhibitor
  • HIV infection
  • Maraviroc
  • PRO 140
  • R5
  • R5X4
  • Vicriviroc
  • Viral tropism
  • X4

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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