Access to treatment for HBV infection and its consistency with 2008 European guidelines in a multicentre cross-sectional study of HIV/HBV co-infected patients in Italy

Giorgio Antonucci, Francesco Mazzotta, Claudio Angeletti, Enrico Girardi, Massimo Puoti, Giulio De Stefano, Paolo Grossi, Nicola Petrosillo, Gabriella Pagano, Giovanni Cassola, Anna Orani, Caterina Sagnelli, Orlando Armignacco, Evangelista Sagnelli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: A survey was performed in 2008 to evaluate the profiles of patients with chronic hepatitis B cared for by Italian Infectious Diseases Centers (IDCs).This analysis describes: i) factors associated with access to the anti-HBV treatment in a cohort of HIV/HBV co-infected patients cared for in tertiary centers of a developed country with comprehensive coverage under the National Health System (NHS); ii) consistency of current anti-HBV regimens with specific European guidelines in force at the time of the study and factors associated with the receipt of sub-optimal regimens. Methods. The study focuses on 374 (87.6%) treated patients at some point in their life out of the 427 tested HIV/HBV positive. It is multicentre, cross-sectional in the design. To account for missing values, a Multiple Imputation method is used. Results: Three hundred and thirty-four (89.3%) patients were currently treated. The most common current regimen was combination therapy of tenofovir (TDF) plus LAM/FTC (lamivudine/emtricitabine) (n = 235, 70.4%), as part of antiretroviral treatment.In the multivariate analysis, an increased chance of getting treated was independently associated with increasing years since HBV diagnosis (2-10 years, p 10 years, p

Original languageEnglish
Article number153
JournalBMC Research Notes
Volume6
Issue number1
DOIs
Publication statusPublished - 2013

Keywords

  • Antiviral agents/therapeutic use
  • Cohort study
  • Guidelines adherence
  • Health Services accessibility
  • Hepatitis B chronic
  • HIV infections/complications

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint Dive into the research topics of 'Access to treatment for HBV infection and its consistency with 2008 European guidelines in a multicentre cross-sectional study of HIV/HBV co-infected patients in Italy'. Together they form a unique fingerprint.

Cite this