Accumulation of cells with short telomeres is associated with impaired zinc homeostasis and inflammation in old hypertensive participants

Catia Cipriano, Silvia Tesei, Marco Malavolta, Robertina Giacconi, Elisa Muti, Laura Costarelli, Francesco Piacenza, Sara Pierpaoli, Roberta Galeazzi, Maria Blasco, Elsa Vera, Andres Canela, Fabrizia Lattanzio, Eugenio Mocchegiani

Research output: Contribution to journalArticle

Abstract

Critical shortening of telomeres, likely associated with a considerable increase of senescent cells, can be observed in PBMC of individuals aged 80 and older. We investigated the relationship between critical telomere shortening and zinc status in healthy or hypertensive participants with or without cardiovascular disease in old and very old participants. Telomere shortening and accumulation of cells with short telomeres (percent of cells with short telomeres) in advancing age was evident in patients and healthy controls, but exacerbated in those patients aged 80 and older. Moreover, in very old patients, the accumulation of % CST may impair intracellular zinc homeostasis and metallothioneins expression, which itself is linked to an increased number of inflammatory agents, thereby suggesting the existence of a possible causal relationship between % CST and zinc homeostasis. The determination of % CST could be a more reliable means than the simple measure of telomere length as fundamental parameter in ageing to determine whether individuals are still able to respond to stress.

Original languageEnglish
Pages (from-to)745-751
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume64
Issue number7
DOIs
Publication statusPublished - Jul 2009

Keywords

  • Cell senescence
  • Hypertension
  • Inflammation
  • Metallothioneins
  • Zinc

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology
  • Medicine(all)

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