Abstract
Critical shortening of telomeres, likely associated with a considerable increase of senescent cells, can be observed in PBMC of individuals aged 80 and older. We investigated the relationship between critical telomere shortening and zinc status in healthy or hypertensive participants with or without cardiovascular disease in old and very old participants. Telomere shortening and accumulation of cells with short telomeres (percent of cells with short telomeres) in advancing age was evident in patients and healthy controls, but exacerbated in those patients aged 80 and older. Moreover, in very old patients, the accumulation of % CST may impair intracellular zinc homeostasis and metallothioneins expression, which itself is linked to an increased number of inflammatory agents, thereby suggesting the existence of a possible causal relationship between % CST and zinc homeostasis. The determination of % CST could be a more reliable means than the simple measure of telomere length as fundamental parameter in ageing to determine whether individuals are still able to respond to stress.
| Original language | English |
|---|---|
| Pages (from-to) | 745-751 |
| Number of pages | 7 |
| Journal | Journals of Gerontology - Series A Biological Sciences and Medical Sciences |
| Volume | 64 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2009 |
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Keywords
- Cell senescence
- Hypertension
- Inflammation
- Metallothioneins
- Zinc
ASJC Scopus subject areas
- Ageing
- Geriatrics and Gerontology
- Medicine(all)
Cite this
Accumulation of cells with short telomeres is associated with impaired zinc homeostasis and inflammation in old hypertensive participants. / Cipriano, Catia; Tesei, Silvia; Malavolta, Marco; Giacconi, Robertina; Muti, Elisa; Costarelli, Laura; Piacenza, Francesco; Pierpaoli, Sara; Galeazzi, Roberta; Blasco, Maria; Vera, Elsa; Canela, Andres; Lattanzio, Fabrizia; Mocchegiani, Eugenio.
In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 64, No. 7, 07.2009, p. 745-751.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Accumulation of cells with short telomeres is associated with impaired zinc homeostasis and inflammation in old hypertensive participants
AU - Cipriano, Catia
AU - Tesei, Silvia
AU - Malavolta, Marco
AU - Giacconi, Robertina
AU - Muti, Elisa
AU - Costarelli, Laura
AU - Piacenza, Francesco
AU - Pierpaoli, Sara
AU - Galeazzi, Roberta
AU - Blasco, Maria
AU - Vera, Elsa
AU - Canela, Andres
AU - Lattanzio, Fabrizia
AU - Mocchegiani, Eugenio
PY - 2009/7
Y1 - 2009/7
N2 - Critical shortening of telomeres, likely associated with a considerable increase of senescent cells, can be observed in PBMC of individuals aged 80 and older. We investigated the relationship between critical telomere shortening and zinc status in healthy or hypertensive participants with or without cardiovascular disease in old and very old participants. Telomere shortening and accumulation of cells with short telomeres (percent of cells with short telomeres) in advancing age was evident in patients and healthy controls, but exacerbated in those patients aged 80 and older. Moreover, in very old patients, the accumulation of % CST may impair intracellular zinc homeostasis and metallothioneins expression, which itself is linked to an increased number of inflammatory agents, thereby suggesting the existence of a possible causal relationship between % CST and zinc homeostasis. The determination of % CST could be a more reliable means than the simple measure of telomere length as fundamental parameter in ageing to determine whether individuals are still able to respond to stress.
AB - Critical shortening of telomeres, likely associated with a considerable increase of senescent cells, can be observed in PBMC of individuals aged 80 and older. We investigated the relationship between critical telomere shortening and zinc status in healthy or hypertensive participants with or without cardiovascular disease in old and very old participants. Telomere shortening and accumulation of cells with short telomeres (percent of cells with short telomeres) in advancing age was evident in patients and healthy controls, but exacerbated in those patients aged 80 and older. Moreover, in very old patients, the accumulation of % CST may impair intracellular zinc homeostasis and metallothioneins expression, which itself is linked to an increased number of inflammatory agents, thereby suggesting the existence of a possible causal relationship between % CST and zinc homeostasis. The determination of % CST could be a more reliable means than the simple measure of telomere length as fundamental parameter in ageing to determine whether individuals are still able to respond to stress.
KW - Cell senescence
KW - Hypertension
KW - Inflammation
KW - Metallothioneins
KW - Zinc
UR - http://www.scopus.com/inward/record.url?scp=67649657879&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649657879&partnerID=8YFLogxK
U2 - 10.1093/gerona/glp048
DO - 10.1093/gerona/glp048
M3 - Article
C2 - 19359441
AN - SCOPUS:67649657879
VL - 64
SP - 745
EP - 751
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
SN - 1079-5006
IS - 7
ER -