Abstract
Objective: To compare six strategies using digital breast tomosynthesis in women with mammographically negative dense breasts. Materials and methods: This is a substudy of the ‘ASTOUND’ trial. 163 women who underwent tomosynthesis with synthetically reconstructed projection images (S-2D) inclusive of 13 (7.9%) cases diagnosed with breast cancer at histopathology after surgery were evaluated. Accuracy measures and screen-reading time of six reading strategies were assessed: (A) Single reading of S-2D alone, (B) single reading of tomosynthesis alone, (C) single reading of joint interpretation of tomosynthesis + S-2D, (D) double-reading of S-2D alone, (E) double reading of tomosynthesis alone, (F) double reading of joint interpretation of tomosynthesis + S-2D. Results: The median age of the patients was 53 years (range, 36–88 years). The highest global accuracy was obtained with double reading of tomosynthesis + S2D (F) with an AUC of 0.979 (p<0.001) and a mean reading time of 154 s versus 34 s for the fastest strategy (single reading of S-2D alone). The AUCs for the other five strategies did not differ from each other. Conclusion: Double reading of tomosynthesis+ S2D had the best accuracy of six screen-reading strategies although it had the longest reading time. Key Points: • Tomosynthesis acquisitions are progressively implemented with reconstructed synthesized 2D images • Double reading using S-2D plus tomosynthesis had the highest global accuracy (p<0.001). • Double reading of S-2D plus tomosynthesis increased reading time.
| Original language | English |
|---|---|
| Pages (from-to) | 5179-5184 |
| Number of pages | 6 |
| Journal | European Radiology |
| Volume | 27 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1 2017 |
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Keywords
- Accuracy
- Breast density
- Dense breasts
- Digital Breast Tomosynthesis
- Reading time
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Accuracy and reading time for six strategies using digital breast tomosynthesis in women with mammographically negative dense breasts. / Tagliafico, Alberto Stefano; Calabrese, Massimo; Bignotti, Bianca; Signori, Alessio; Fisci, Erica; Rossi, Federica; Valdora, Francesca; Houssami, Nehmat.
In: European Radiology, Vol. 27, No. 12, 01.12.2017, p. 5179-5184.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Accuracy and reading time for six strategies using digital breast tomosynthesis in women with mammographically negative dense breasts
AU - Tagliafico, Alberto Stefano
AU - Calabrese, Massimo
AU - Bignotti, Bianca
AU - Signori, Alessio
AU - Fisci, Erica
AU - Rossi, Federica
AU - Valdora, Francesca
AU - Houssami, Nehmat
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Objective: To compare six strategies using digital breast tomosynthesis in women with mammographically negative dense breasts. Materials and methods: This is a substudy of the ‘ASTOUND’ trial. 163 women who underwent tomosynthesis with synthetically reconstructed projection images (S-2D) inclusive of 13 (7.9%) cases diagnosed with breast cancer at histopathology after surgery were evaluated. Accuracy measures and screen-reading time of six reading strategies were assessed: (A) Single reading of S-2D alone, (B) single reading of tomosynthesis alone, (C) single reading of joint interpretation of tomosynthesis + S-2D, (D) double-reading of S-2D alone, (E) double reading of tomosynthesis alone, (F) double reading of joint interpretation of tomosynthesis + S-2D. Results: The median age of the patients was 53 years (range, 36–88 years). The highest global accuracy was obtained with double reading of tomosynthesis + S2D (F) with an AUC of 0.979 (p<0.001) and a mean reading time of 154 s versus 34 s for the fastest strategy (single reading of S-2D alone). The AUCs for the other five strategies did not differ from each other. Conclusion: Double reading of tomosynthesis+ S2D had the best accuracy of six screen-reading strategies although it had the longest reading time. Key Points: • Tomosynthesis acquisitions are progressively implemented with reconstructed synthesized 2D images • Double reading using S-2D plus tomosynthesis had the highest global accuracy (p<0.001). • Double reading of S-2D plus tomosynthesis increased reading time.
AB - Objective: To compare six strategies using digital breast tomosynthesis in women with mammographically negative dense breasts. Materials and methods: This is a substudy of the ‘ASTOUND’ trial. 163 women who underwent tomosynthesis with synthetically reconstructed projection images (S-2D) inclusive of 13 (7.9%) cases diagnosed with breast cancer at histopathology after surgery were evaluated. Accuracy measures and screen-reading time of six reading strategies were assessed: (A) Single reading of S-2D alone, (B) single reading of tomosynthesis alone, (C) single reading of joint interpretation of tomosynthesis + S-2D, (D) double-reading of S-2D alone, (E) double reading of tomosynthesis alone, (F) double reading of joint interpretation of tomosynthesis + S-2D. Results: The median age of the patients was 53 years (range, 36–88 years). The highest global accuracy was obtained with double reading of tomosynthesis + S2D (F) with an AUC of 0.979 (p<0.001) and a mean reading time of 154 s versus 34 s for the fastest strategy (single reading of S-2D alone). The AUCs for the other five strategies did not differ from each other. Conclusion: Double reading of tomosynthesis+ S2D had the best accuracy of six screen-reading strategies although it had the longest reading time. Key Points: • Tomosynthesis acquisitions are progressively implemented with reconstructed synthesized 2D images • Double reading using S-2D plus tomosynthesis had the highest global accuracy (p<0.001). • Double reading of S-2D plus tomosynthesis increased reading time.
KW - Accuracy
KW - Breast density
KW - Dense breasts
KW - Digital Breast Tomosynthesis
KW - Reading time
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U2 - 10.1007/s00330-017-4918-5
DO - 10.1007/s00330-017-4918-5
M3 - Article
VL - 27
SP - 5179
EP - 5184
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 12
ER -