Abstract
Objective: To compare six strategies using digital breast tomosynthesis in women with mammographically negative dense breasts. Materials and methods: This is a substudy of the ‘ASTOUND’ trial. 163 women who underwent tomosynthesis with synthetically reconstructed projection images (S-2D) inclusive of 13 (7.9%) cases diagnosed with breast cancer at histopathology after surgery were evaluated. Accuracy measures and screen-reading time of six reading strategies were assessed: (A) Single reading of S-2D alone, (B) single reading of tomosynthesis alone, (C) single reading of joint interpretation of tomosynthesis + S-2D, (D) double-reading of S-2D alone, (E) double reading of tomosynthesis alone, (F) double reading of joint interpretation of tomosynthesis + S-2D. Results: The median age of the patients was 53 years (range, 36–88 years). The highest global accuracy was obtained with double reading of tomosynthesis + S2D (F) with an AUC of 0.979 (p<0.001) and a mean reading time of 154 s versus 34 s for the fastest strategy (single reading of S-2D alone). The AUCs for the other five strategies did not differ from each other. Conclusion: Double reading of tomosynthesis+ S2D had the best accuracy of six screen-reading strategies although it had the longest reading time. Key Points: • Tomosynthesis acquisitions are progressively implemented with reconstructed synthesized 2D images • Double reading using S-2D plus tomosynthesis had the highest global accuracy (p<0.001). • Double reading of S-2D plus tomosynthesis increased reading time.
Original language | English |
---|---|
Pages (from-to) | 5179-5184 |
Number of pages | 6 |
Journal | European Radiology |
Volume | 27 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 1 2017 |
Keywords
- Accuracy
- Breast density
- Dense breasts
- Digital Breast Tomosynthesis
- Reading time
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging