Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis

Valerio Nobili, Francesco Vizzutti, Umberto Arena, Juan G. Abraldes, Fabio Marra, Andrea Pietrobattista, Rodolfo Fruhwirth, Matilde Marcellini, Massimo Pinzani

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Abstract

Transient elastography (TE) has received increasing attention as a means to evaluate disease progression in chronic liver disease patients. In this study, we assessed the value of TE for the prediction of fibrosis stage in a cohort of pediatric patients with nonalcoholic steatohepatitis. Furthermore, TE interobserver agreement was evaluated. TE was performed in 52 consecutive biopsy-proven nonalcoholic steatohepatitis patients (32 males, 20 females, age 13.6 ± 2.44 years). The area under the receiver operating characteristic curves for the prediction of "any" (≥1), significant (≥2), or advanced fibrosis (≥3) were 0.977, 0.992, and 1, respectively. Calculation of multilevel likelihood ratios showed that TE values

Original languageEnglish
Pages (from-to)442-448
Number of pages7
JournalHepatology
Volume48
Issue number2
DOIs
Publication statusPublished - Aug 2008

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Elasticity Imaging Techniques
Fibrosis
Pediatrics
ROC Curve
Disease Progression
Liver Diseases
Chronic Disease
Non-alcoholic Fatty Liver Disease
Biopsy

ASJC Scopus subject areas

  • Hepatology

Cite this

Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis. / Nobili, Valerio; Vizzutti, Francesco; Arena, Umberto; Abraldes, Juan G.; Marra, Fabio; Pietrobattista, Andrea; Fruhwirth, Rodolfo; Marcellini, Matilde; Pinzani, Massimo.

In: Hepatology, Vol. 48, No. 2, 08.2008, p. 442-448.

Research output: Contribution to journalArticle

Nobili, V, Vizzutti, F, Arena, U, Abraldes, JG, Marra, F, Pietrobattista, A, Fruhwirth, R, Marcellini, M & Pinzani, M 2008, 'Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis', Hepatology, vol. 48, no. 2, pp. 442-448. https://doi.org/10.1002/hep.22376
Nobili, Valerio ; Vizzutti, Francesco ; Arena, Umberto ; Abraldes, Juan G. ; Marra, Fabio ; Pietrobattista, Andrea ; Fruhwirth, Rodolfo ; Marcellini, Matilde ; Pinzani, Massimo. / Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis. In: Hepatology. 2008 ; Vol. 48, No. 2. pp. 442-448.
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