Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis

Valerio Nobili; Francesco Vizzutti; Umberto Arena; Juan G. Abraldes; Fabio Marra; Andrea Pietrobattista; Rodolfo Fruhwirth; Matilde Marcellini; Massimo Pinzani

doi:10.1002/hep.22376

Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis

Valerio Nobili, Francesco Vizzutti, Umberto Arena, Juan G. Abraldes, Fabio Marra, Andrea Pietrobattista, Rodolfo Fruhwirth, Matilde Marcellini, Massimo Pinzani

Ospedale Pediatrico Bambino Gesu

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Abstract

Transient elastography (TE) has received increasing attention as a means to evaluate disease progression in chronic liver disease patients. In this study, we assessed the value of TE for the prediction of fibrosis stage in a cohort of pediatric patients with nonalcoholic steatohepatitis. Furthermore, TE interobserver agreement was evaluated. TE was performed in 52 consecutive biopsy-proven nonalcoholic steatohepatitis patients (32 males, 20 females, age 13.6 ± 2.44 years). The area under the receiver operating characteristic curves for the prediction of "any" (≥1), significant (≥2), or advanced fibrosis (≥3) were 0.977, 0.992, and 1, respectively. Calculation of multilevel likelihood ratios showed that TE values

Original language	English
Pages (from-to)	442-448
Number of pages	7
Journal	Hepatology
Volume	48
Issue number	2
DOIs	https://doi.org/10.1002/hep.22376
Publication status	Published - Aug 2008

ASJC Scopus subject areas

Hepatology

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10.1002/hep.22376

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Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis. / Nobili, Valerio; Vizzutti, Francesco; Arena, Umberto; Abraldes, Juan G.; Marra, Fabio; Pietrobattista, Andrea; Fruhwirth, Rodolfo; Marcellini, Matilde; Pinzani, Massimo.

In: Hepatology, Vol. 48, No. 2, 08.2008, p. 442-448.

Research output: Contribution to journal › Article › peer-review

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AU - Vizzutti, Francesco

AU - Arena, Umberto

AU - Abraldes, Juan G.

AU - Marra, Fabio

AU - Pietrobattista, Andrea

AU - Fruhwirth, Rodolfo

AU - Marcellini, Matilde

AU - Pinzani, Massimo

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Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis

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