Accuracy of cholesterol measurements in Italian clinical laboratories. Joint Project GISSI Prevention - Italian Society of Clinical Biochemistry

M. S. Graziani, F. Ceriotti, A. Carobene, A. Modenese, C. Ferrero, E. De Giorgi, M. Franzin, C. Marchetti, P. Brambilla, M. Bertona, D. Giannone, G. Righetti, A. Marocchi, L. Prencipe, C. Franzini, P. Luraschi, P. Mocarelli, F. Bordone, S. Mattathil, B. MarinielloA. Savarino, N. Panzini, A. Fuscio, V. Siclari, G. Pedicini, L. Robba, P. Bandello, E. Vinci, V. Malacrida, A. V. Carluccio, F. Carmignoto, P. De Ambrogio, R. Romano, G. Spagnoletti, M. Condorelli, E. Gulletta, M. Guarguaglini, A. Bianchi-Bosisio, R. Airo, N. Di Sciascio, G. Neri, R. Antinozzi, G. Panciroli, C. Perazzi, G. De Leo, P. Berti, A. Biddau, L. Marchetti, S. Bossini, M. Martinelli, G. Baldini, G. Aureli, M. Golato, M. Venturini, E. Troina, M. Mancosu, P. Cicatelli, C. Ottomano, P. Ferrante, A. Berlusconi, L. Bianco, J. L. Carati, M. Bolletti-Censi, R. De Capua, C. Aquili, B. Scola, F. Manzo, F. Borsellino, G. Nubile, M. Romagnoli, A. Ridolfi, M. Bartolucci, P. Apicella, R. Pace, P. Casertano, F. Callegaris, B. Innocenti, P. Mammini, P. Cappelletti, G. Pendino, M. Cavalleri, G. B. Volpones, O. Recchia, R. Benedetti, G. Casparrini, M. Macchiolo, V. Bazzanti Vestri, A. Bianchini, F. Barbieri-Palmieri, S. Craca, L. Tiraboschi, L. Guerrini, R. Pagni, E. Capra, C. Vultaggio, E. Paltrinieri, E. Di Carlo, M. Colombo, G. Lo Monaco

Research output: Contribution to journalArticlepeer-review

Abstract

We report the results of an external quality assessment scheme for serum total cholesterol measurement involving about 100 Italian laboratories participating in an epidemiological study of post myocardial infarction. Two frozen human serum pools with Abell-Kendall assigned values are distributed quarterly at the laboratories (up to now seven events occurred); the obtained results are evaluated and discussed. In one exercise (5) duplicated measurements were repeated on three different days. Eighty-five to 98% of the laboratories obtained results within the total error limits (± 8.9%). But, while precision (calculated on the six replicates of exercise 5) is good (90% of the laboratories obtained CV <3%), inaccuracy problems are evident in every event. Indeed the mean bias from the reference method value ranged from 1.54 and 3.49% in the various events.

Original languageEnglish
Pages (from-to)311-315
Number of pages5
JournalEuropean Journal of Clinical Chemistry and Clinical Biochemistry
Volume35
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Clinical Biochemistry

Fingerprint

Dive into the research topics of 'Accuracy of cholesterol measurements in Italian clinical laboratories. Joint Project GISSI Prevention - Italian Society of Clinical Biochemistry'. Together they form a unique fingerprint.

Cite this