Accuracy of different methods for susceptibility testing of gentamicin with KPC carbapenemase-producing Klebsiella pneumoniae

Fabio Arena, Tommaso Giani, Guendalina Vaggelli, Giovanni Terenzi, Patrizia Pecile, Gian Maria Rossolini

Research output: Contribution to journalArticlepeer-review

Abstract

Performance of Vitek2, Etest, and TREK broth microdilution (BMD) panels was evaluated versus reference CLSI BMD for gentamicin susceptibility testing with 57 bloodstream isolates of KPC-producing Klebsiella pneumoniae. Compared with reference BMD, the Essential Agreement and Categorical Agreement for TREK panels, Vitek2, and Etest were 91.2%, 31.6%, and 61.4%, respectively, and 86%, 21%, and 52.6%, respectively. Four very major discrepancies occurred with Vitek2. In these 4 strains, gentamicin resistance was associated with the presence of an armA aminoglycoside resistance determinant.

Original languageEnglish
Pages (from-to)132-134
Number of pages3
JournalDiagnostic Microbiology and Infectious Disease
Volume81
Issue number2
DOIs
Publication statusPublished - 2015

Keywords

  • Aminoglycosides
  • Automated system
  • Broth microdilution
  • Carbapenem-resistant
  • Etest
  • Klebsiella pneumoniae
  • Vitek2

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Medicine(all)

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