Accuracy of fine-needle aspiration cytology in detecting cervical node metastasis after radiotherapy: Systematic review and meta-analysis

Andrea Costantino, Giuseppe Mercante, Elisa D'Ascoli, Fabio Ferreli, Luca Di Tommaso, Ciro Franzese, Caterina Giannitto, Manuele Casale, Giuseppe Spriano, Armando De Virgilio

Research output: Contribution to journalReview articlepeer-review

Abstract

PURPOSE: To define the accuracy of fine-needle aspiration cytology (FNAC) in diagnosing persistent or recurrent neck metastases in previously irradiated patients.

METHODS: The study was performed according to the PRISMA-DTA guidelines.

RESULTS: A total of 382 FNACs were used for calculation of diagnostic accuracy parameters. The overall pooled sensitivity and specificity in detecting malignant nodes were 69.1% (95% CI: 56.3%-80.7%; I2 = 79.5%) and 84.2% (95% CI: 71.8%-93.5%; I2 = 87.0%), respectively. Cumulative diagnostic odds ratio (DOR) was 16.54 (95% CI: 4.89-38.99; I2 = 65.8%), while cumulative positive and negative likelihood ratio (PLR and NLR) were 5.4 (95% CI: 2.3-11.2) and 0.37 (95% CI: 0.22-0.54), respectively.

CONCLUSIONS: FNAC alone could not guide the decision to perform a salvage neck dissection in previously irradiated patients, but its results should be assessed in relation to the specific clinical context.

Original languageEnglish
JournalHead and Neck Surgery
DOIs
Publication statusE-pub ahead of print - Nov 9 2020

Fingerprint Dive into the research topics of 'Accuracy of fine-needle aspiration cytology in detecting cervical node metastasis after radiotherapy: Systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this