Accuracy of fine-needle aspiration cytology in detecting cervical node metastasis after radiotherapy: Systematic review and meta-analysis

Andrea Costantino; Giuseppe Mercante; Elisa D'Ascoli; Fabio Ferreli; Luca Di Tommaso; Ciro Franzese; Caterina Giannitto; Manuele Casale; Giuseppe Spriano; Armando De Virgilio

doi:10.1002/hed.26536

Accuracy of fine-needle aspiration cytology in detecting cervical node metastasis after radiotherapy: Systematic review and meta-analysis

Andrea Costantino, Giuseppe Mercante, Elisa D'Ascoli, Fabio Ferreli, Luca Di Tommaso, Ciro Franzese, Caterina Giannitto, Manuele Casale, Giuseppe Spriano, Armando De Virgilio

Istituto Clinico Humanitas

Research output: Contribution to journal › Review article › peer-review

Abstract

PURPOSE: To define the accuracy of fine-needle aspiration cytology (FNAC) in diagnosing persistent or recurrent neck metastases in previously irradiated patients.

METHODS: The study was performed according to the PRISMA-DTA guidelines.

RESULTS: A total of 382 FNACs were used for calculation of diagnostic accuracy parameters. The overall pooled sensitivity and specificity in detecting malignant nodes were 69.1% (95% CI: 56.3%-80.7%; I2 = 79.5%) and 84.2% (95% CI: 71.8%-93.5%; I2 = 87.0%), respectively. Cumulative diagnostic odds ratio (DOR) was 16.54 (95% CI: 4.89-38.99; I2 = 65.8%), while cumulative positive and negative likelihood ratio (PLR and NLR) were 5.4 (95% CI: 2.3-11.2) and 0.37 (95% CI: 0.22-0.54), respectively.

CONCLUSIONS: FNAC alone could not guide the decision to perform a salvage neck dissection in previously irradiated patients, but its results should be assessed in relation to the specific clinical context.

Original language	English
Journal	Head and Neck Surgery
DOIs	https://doi.org/10.1002/hed.26536
Publication status	E-pub ahead of print - Nov 9 2020

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Accuracy of fine-needle aspiration cytology in detecting cervical node metastasis after radiotherapy : Systematic review and meta-analysis. / Costantino, Andrea; Mercante, Giuseppe; D'Ascoli, Elisa; Ferreli, Fabio; Di Tommaso, Luca ; Franzese, Ciro ; Giannitto, Caterina; Casale, Manuele; Spriano, Giuseppe ; De Virgilio, Armando.

In: Head and Neck Surgery, 09.11.2020.

Research output: Contribution to journal › Review article › peer-review

Costantino, Andrea ; Mercante, Giuseppe ; D'Ascoli, Elisa ; Ferreli, Fabio ; Di Tommaso, Luca ; Franzese, Ciro ; Giannitto, Caterina ; Casale, Manuele ; Spriano, Giuseppe ; De Virgilio, Armando. / Accuracy of fine-needle aspiration cytology in detecting cervical node metastasis after radiotherapy : Systematic review and meta-analysis. In: Head and Neck Surgery. 2020.

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title = "Accuracy of fine-needle aspiration cytology in detecting cervical node metastasis after radiotherapy: Systematic review and meta-analysis",

abstract = "PURPOSE: To define the accuracy of fine-needle aspiration cytology (FNAC) in diagnosing persistent or recurrent neck metastases in previously irradiated patients.METHODS: The study was performed according to the PRISMA-DTA guidelines.RESULTS: A total of 382 FNACs were used for calculation of diagnostic accuracy parameters. The overall pooled sensitivity and specificity in detecting malignant nodes were 69.1% (95% CI: 56.3%-80.7%; I2 = 79.5%) and 84.2% (95% CI: 71.8%-93.5%; I2 = 87.0%), respectively. Cumulative diagnostic odds ratio (DOR) was 16.54 (95% CI: 4.89-38.99; I2 = 65.8%), while cumulative positive and negative likelihood ratio (PLR and NLR) were 5.4 (95% CI: 2.3-11.2) and 0.37 (95% CI: 0.22-0.54), respectively.CONCLUSIONS: FNAC alone could not guide the decision to perform a salvage neck dissection in previously irradiated patients, but its results should be assessed in relation to the specific clinical context.",

author = "Andrea Costantino and Giuseppe Mercante and Elisa D'Ascoli and Fabio Ferreli and {Di Tommaso}, Luca and Ciro Franzese and Caterina Giannitto and Manuele Casale and Giuseppe Spriano and {De Virgilio}, Armando",

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doi = "10.1002/hed.26536",

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T1 - Accuracy of fine-needle aspiration cytology in detecting cervical node metastasis after radiotherapy

T2 - Systematic review and meta-analysis

AU - Costantino, Andrea

AU - Mercante, Giuseppe

AU - D'Ascoli, Elisa

AU - Ferreli, Fabio

AU - Di Tommaso, Luca

AU - Franzese, Ciro

AU - Giannitto, Caterina

AU - Casale, Manuele

AU - Spriano, Giuseppe

AU - De Virgilio, Armando

PY - 2020/11/9

Y1 - 2020/11/9

N2 - PURPOSE: To define the accuracy of fine-needle aspiration cytology (FNAC) in diagnosing persistent or recurrent neck metastases in previously irradiated patients.METHODS: The study was performed according to the PRISMA-DTA guidelines.RESULTS: A total of 382 FNACs were used for calculation of diagnostic accuracy parameters. The overall pooled sensitivity and specificity in detecting malignant nodes were 69.1% (95% CI: 56.3%-80.7%; I2 = 79.5%) and 84.2% (95% CI: 71.8%-93.5%; I2 = 87.0%), respectively. Cumulative diagnostic odds ratio (DOR) was 16.54 (95% CI: 4.89-38.99; I2 = 65.8%), while cumulative positive and negative likelihood ratio (PLR and NLR) were 5.4 (95% CI: 2.3-11.2) and 0.37 (95% CI: 0.22-0.54), respectively.CONCLUSIONS: FNAC alone could not guide the decision to perform a salvage neck dissection in previously irradiated patients, but its results should be assessed in relation to the specific clinical context.

AB - PURPOSE: To define the accuracy of fine-needle aspiration cytology (FNAC) in diagnosing persistent or recurrent neck metastases in previously irradiated patients.METHODS: The study was performed according to the PRISMA-DTA guidelines.RESULTS: A total of 382 FNACs were used for calculation of diagnostic accuracy parameters. The overall pooled sensitivity and specificity in detecting malignant nodes were 69.1% (95% CI: 56.3%-80.7%; I2 = 79.5%) and 84.2% (95% CI: 71.8%-93.5%; I2 = 87.0%), respectively. Cumulative diagnostic odds ratio (DOR) was 16.54 (95% CI: 4.89-38.99; I2 = 65.8%), while cumulative positive and negative likelihood ratio (PLR and NLR) were 5.4 (95% CI: 2.3-11.2) and 0.37 (95% CI: 0.22-0.54), respectively.CONCLUSIONS: FNAC alone could not guide the decision to perform a salvage neck dissection in previously irradiated patients, but its results should be assessed in relation to the specific clinical context.

U2 - 10.1002/hed.26536

DO - 10.1002/hed.26536

M3 - Review article

C2 - 33166002

JO - Head and Neck Surgery

JF - Head and Neck Surgery

SN - 1043-3074

ER -