Accuracy of fine needle aspiration cytology in the pathological typing of non-small cell lung cancer

Rita Nizzoli, Marcello Tiseo, Francesco Gelsomino, Marco Bartolotti, Maria Majori, Lilia Ferrari, Massimo De Filippo, Guido Rindi, Enrico Maria Silini, Annamaria Guazzi, Andrea Ardizzoni

Research output: Contribution to journalArticle

Abstract

Background: Histological typing of non-small cell lung cancer (NSCLC) has an increasing clinical relevance due to the emerging differences in medical treatment between squamous and nonsquamous tumors. However, most NSCLCs are diagnosed in an advanced stage, and the diagnosis is often obtained exclusively by cytology either exfoliative or following fine needle aspiration. We investigated the accuracy of fine needle aspiration cytology (FNAC) in NSCLC typing as compared with histology. Methods: Over the period 2000-2009, 1182 transbronchial needle aspirate or transthoracic needle aspirate samples were obtained from patients with suspicious thoracic lesions. In 474 patients, a cytological diagnosis of primary NSCLC was obtained, and 186 (39%) of them (108 transbronchial needle aspirates and 78 transthoracic needle aspirates) received a parallel or subsequent histologic diagnosis on endoscopic biopsy (112) or surgery (74). Results: At cytology, 158 (85%) NSCLC cases were typed (89 adenocarcinoma and 69 squamous cell carcinoma), while 28 (15%) were classified as NSCLC not otherwise specified. At histology, 183 (98%) cases were typed (109 adenocarcinoma, 69 squamous cell carcinoma, 3 adenosquamous carcinoma, and 2 large cell carcinoma), and only 3 (2%) were classified as NSCLC not otherwise specified. Cytological and histological typing was concordant in 137 of 156 (88%) cases (K = 0.755; p <0.001). The positive predictive value of FNAC in typing NSCLC was 92% for adenocarcinoma and 82% for squamous cell carcinoma. Conclusion: FNAC in expert hands is fairly accurate for typing NSCLC and can be regarded as an acceptable procedure for diagnostic and medical treatment planning purposes in most NSCLC cases, especially when more invasive approaches are unfeasible. In poorly differentiated and doubtful cases, the use of ancillary techniques, such as immunocytochemistry, may be required to improve the diagnostic yield.

Original languageEnglish
Pages (from-to)489-493
Number of pages5
JournalJournal of Thoracic Oncology
Volume6
Issue number3
DOIs
Publication statusPublished - Mar 2011

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Fine Needle Biopsy
Non-Small Cell Lung Carcinoma
Cell Biology
Needles
Squamous Cell Carcinoma
Adenocarcinoma
Histology
Adenosquamous Carcinoma
Large Cell Carcinoma
Thorax
Hand
Immunohistochemistry
Biopsy
Therapeutics

Keywords

  • Adenocarcinoma
  • Cytology
  • Histology
  • NSCLC
  • NSCLC-NOS
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Nizzoli, R., Tiseo, M., Gelsomino, F., Bartolotti, M., Majori, M., Ferrari, L., ... Ardizzoni, A. (2011). Accuracy of fine needle aspiration cytology in the pathological typing of non-small cell lung cancer. Journal of Thoracic Oncology, 6(3), 489-493. https://doi.org/10.1097/JTO.0b013e31820b86cb

Accuracy of fine needle aspiration cytology in the pathological typing of non-small cell lung cancer. / Nizzoli, Rita; Tiseo, Marcello; Gelsomino, Francesco; Bartolotti, Marco; Majori, Maria; Ferrari, Lilia; De Filippo, Massimo; Rindi, Guido; Silini, Enrico Maria; Guazzi, Annamaria; Ardizzoni, Andrea.

In: Journal of Thoracic Oncology, Vol. 6, No. 3, 03.2011, p. 489-493.

Research output: Contribution to journalArticle

Nizzoli, R, Tiseo, M, Gelsomino, F, Bartolotti, M, Majori, M, Ferrari, L, De Filippo, M, Rindi, G, Silini, EM, Guazzi, A & Ardizzoni, A 2011, 'Accuracy of fine needle aspiration cytology in the pathological typing of non-small cell lung cancer', Journal of Thoracic Oncology, vol. 6, no. 3, pp. 489-493. https://doi.org/10.1097/JTO.0b013e31820b86cb
Nizzoli, Rita ; Tiseo, Marcello ; Gelsomino, Francesco ; Bartolotti, Marco ; Majori, Maria ; Ferrari, Lilia ; De Filippo, Massimo ; Rindi, Guido ; Silini, Enrico Maria ; Guazzi, Annamaria ; Ardizzoni, Andrea. / Accuracy of fine needle aspiration cytology in the pathological typing of non-small cell lung cancer. In: Journal of Thoracic Oncology. 2011 ; Vol. 6, No. 3. pp. 489-493.
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abstract = "Background: Histological typing of non-small cell lung cancer (NSCLC) has an increasing clinical relevance due to the emerging differences in medical treatment between squamous and nonsquamous tumors. However, most NSCLCs are diagnosed in an advanced stage, and the diagnosis is often obtained exclusively by cytology either exfoliative or following fine needle aspiration. We investigated the accuracy of fine needle aspiration cytology (FNAC) in NSCLC typing as compared with histology. Methods: Over the period 2000-2009, 1182 transbronchial needle aspirate or transthoracic needle aspirate samples were obtained from patients with suspicious thoracic lesions. In 474 patients, a cytological diagnosis of primary NSCLC was obtained, and 186 (39{\%}) of them (108 transbronchial needle aspirates and 78 transthoracic needle aspirates) received a parallel or subsequent histologic diagnosis on endoscopic biopsy (112) or surgery (74). Results: At cytology, 158 (85{\%}) NSCLC cases were typed (89 adenocarcinoma and 69 squamous cell carcinoma), while 28 (15{\%}) were classified as NSCLC not otherwise specified. At histology, 183 (98{\%}) cases were typed (109 adenocarcinoma, 69 squamous cell carcinoma, 3 adenosquamous carcinoma, and 2 large cell carcinoma), and only 3 (2{\%}) were classified as NSCLC not otherwise specified. Cytological and histological typing was concordant in 137 of 156 (88{\%}) cases (K = 0.755; p <0.001). The positive predictive value of FNAC in typing NSCLC was 92{\%} for adenocarcinoma and 82{\%} for squamous cell carcinoma. Conclusion: FNAC in expert hands is fairly accurate for typing NSCLC and can be regarded as an acceptable procedure for diagnostic and medical treatment planning purposes in most NSCLC cases, especially when more invasive approaches are unfeasible. In poorly differentiated and doubtful cases, the use of ancillary techniques, such as immunocytochemistry, may be required to improve the diagnostic yield.",
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AU - Bartolotti, Marco

AU - Majori, Maria

AU - Ferrari, Lilia

AU - De Filippo, Massimo

AU - Rindi, Guido

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N2 - Background: Histological typing of non-small cell lung cancer (NSCLC) has an increasing clinical relevance due to the emerging differences in medical treatment between squamous and nonsquamous tumors. However, most NSCLCs are diagnosed in an advanced stage, and the diagnosis is often obtained exclusively by cytology either exfoliative or following fine needle aspiration. We investigated the accuracy of fine needle aspiration cytology (FNAC) in NSCLC typing as compared with histology. Methods: Over the period 2000-2009, 1182 transbronchial needle aspirate or transthoracic needle aspirate samples were obtained from patients with suspicious thoracic lesions. In 474 patients, a cytological diagnosis of primary NSCLC was obtained, and 186 (39%) of them (108 transbronchial needle aspirates and 78 transthoracic needle aspirates) received a parallel or subsequent histologic diagnosis on endoscopic biopsy (112) or surgery (74). Results: At cytology, 158 (85%) NSCLC cases were typed (89 adenocarcinoma and 69 squamous cell carcinoma), while 28 (15%) were classified as NSCLC not otherwise specified. At histology, 183 (98%) cases were typed (109 adenocarcinoma, 69 squamous cell carcinoma, 3 adenosquamous carcinoma, and 2 large cell carcinoma), and only 3 (2%) were classified as NSCLC not otherwise specified. Cytological and histological typing was concordant in 137 of 156 (88%) cases (K = 0.755; p <0.001). The positive predictive value of FNAC in typing NSCLC was 92% for adenocarcinoma and 82% for squamous cell carcinoma. Conclusion: FNAC in expert hands is fairly accurate for typing NSCLC and can be regarded as an acceptable procedure for diagnostic and medical treatment planning purposes in most NSCLC cases, especially when more invasive approaches are unfeasible. In poorly differentiated and doubtful cases, the use of ancillary techniques, such as immunocytochemistry, may be required to improve the diagnostic yield.

AB - Background: Histological typing of non-small cell lung cancer (NSCLC) has an increasing clinical relevance due to the emerging differences in medical treatment between squamous and nonsquamous tumors. However, most NSCLCs are diagnosed in an advanced stage, and the diagnosis is often obtained exclusively by cytology either exfoliative or following fine needle aspiration. We investigated the accuracy of fine needle aspiration cytology (FNAC) in NSCLC typing as compared with histology. Methods: Over the period 2000-2009, 1182 transbronchial needle aspirate or transthoracic needle aspirate samples were obtained from patients with suspicious thoracic lesions. In 474 patients, a cytological diagnosis of primary NSCLC was obtained, and 186 (39%) of them (108 transbronchial needle aspirates and 78 transthoracic needle aspirates) received a parallel or subsequent histologic diagnosis on endoscopic biopsy (112) or surgery (74). Results: At cytology, 158 (85%) NSCLC cases were typed (89 adenocarcinoma and 69 squamous cell carcinoma), while 28 (15%) were classified as NSCLC not otherwise specified. At histology, 183 (98%) cases were typed (109 adenocarcinoma, 69 squamous cell carcinoma, 3 adenosquamous carcinoma, and 2 large cell carcinoma), and only 3 (2%) were classified as NSCLC not otherwise specified. Cytological and histological typing was concordant in 137 of 156 (88%) cases (K = 0.755; p <0.001). The positive predictive value of FNAC in typing NSCLC was 92% for adenocarcinoma and 82% for squamous cell carcinoma. Conclusion: FNAC in expert hands is fairly accurate for typing NSCLC and can be regarded as an acceptable procedure for diagnostic and medical treatment planning purposes in most NSCLC cases, especially when more invasive approaches are unfeasible. In poorly differentiated and doubtful cases, the use of ancillary techniques, such as immunocytochemistry, may be required to improve the diagnostic yield.

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