Accuracy of homogeneous models for photon diffusion in estimating neonatal cerebral hemodynamics by TD-NIRS

CATERINA AMENDOLA, LORENZO SPINELLI, DAVIDE CONTINI, AGNESE DE CARLI, CESARE MARTINELLI, MONICA FUMAGALLI, ALESSANDRO TORRICELLI

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed the accuracy of homogenous (semi-infinite, spherical) photon diffusion models in estimating absolute hemodynamic parameters of the neonatal brain in realistic scenarios (ischemia, hyperoxygenation, and hypoventilation) from 1.5 cm interfiber distance TD NIRS measurements. Time-point-spread-functions in 29- and 44-weeks postmenstrual age head meshes were simulated by the Monte Carlo method, convoluted with a real instrument response function, and then fitted with photon diffusion models. The results show good accuracy in retrieving brain oxygen saturation, and severe underestimation of total cerebral hemoglobin, suggesting the need for more complex models of analysis or of larger interfiber distances to precisely monitor all hemodynamic parameters.

Original languageEnglish
Pages (from-to)1905-1921
Number of pages17
JournalBiomedical Optics Express
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 1 2021

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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