TY - JOUR
T1 - Accuracy of homogeneous models for photon diffusion in estimating neonatal cerebral hemodynamics by TD-NIRS
AU - AMENDOLA, CATERINA
AU - SPINELLI, LORENZO
AU - CONTINI, DAVIDE
AU - DE CARLI, AGNESE
AU - MARTINELLI, CESARE
AU - FUMAGALLI, MONICA
AU - TORRICELLI, ALESSANDRO
N1 - Funding Information:
Acknowledgments. This research was partially funded by the Horizon 2020 Framework Programme of the European Union under grant agreement number 863087.
Publisher Copyright:
© 2021 Optical Society of America.
PY - 2021/4/1
Y1 - 2021/4/1
N2 - We assessed the accuracy of homogenous (semi-infinite, spherical) photon diffusion models in estimating absolute hemodynamic parameters of the neonatal brain in realistic scenarios (ischemia, hyperoxygenation, and hypoventilation) from 1.5 cm interfiber distance TD NIRS measurements. Time-point-spread-functions in 29- and 44-weeks postmenstrual age head meshes were simulated by the Monte Carlo method, convoluted with a real instrument response function, and then fitted with photon diffusion models. The results show good accuracy in retrieving brain oxygen saturation, and severe underestimation of total cerebral hemoglobin, suggesting the need for more complex models of analysis or of larger interfiber distances to precisely monitor all hemodynamic parameters.
AB - We assessed the accuracy of homogenous (semi-infinite, spherical) photon diffusion models in estimating absolute hemodynamic parameters of the neonatal brain in realistic scenarios (ischemia, hyperoxygenation, and hypoventilation) from 1.5 cm interfiber distance TD NIRS measurements. Time-point-spread-functions in 29- and 44-weeks postmenstrual age head meshes were simulated by the Monte Carlo method, convoluted with a real instrument response function, and then fitted with photon diffusion models. The results show good accuracy in retrieving brain oxygen saturation, and severe underestimation of total cerebral hemoglobin, suggesting the need for more complex models of analysis or of larger interfiber distances to precisely monitor all hemodynamic parameters.
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U2 - 10.1364/BOE.417357
DO - 10.1364/BOE.417357
M3 - Article
AN - SCOPUS:85103661204
VL - 12
SP - 1905
EP - 1921
JO - Biomedical Optics Express
JF - Biomedical Optics Express
SN - 2156-7085
IS - 4
ER -