Accuracy of pre-surgical fMRI confirmed by subsequent crossed aphasia

Paolo Vitali, Nina Dronkers, Alexander Pincherle, Anna Rita Giovagnoli, Carlo Marras, Ludovico D'Incerti, Francesco Ghielmetti, Roberto Spreafico, Flavio Villani

Research output: Contribution to journalArticlepeer-review


Atypical patterns of language activation in functional MRI (fMRI) are not unusual, particularly in patients with severe epilepsy. Still, the functional significance of these activations is under debate. We describe a case of a right-handed patient affected by drug-refractory right temporal lobe epilepsy in whom pre-surgical fMRI showed bilateral language activations, greater in the right hemisphere (RH). After surgery, a right subdural hematoma caused epileptic status and severe aphasia. This post-surgical complication of a crossed aphasia confirmed the prior fMRI findings of RH language thus stressing the value of pre-surgical fMRI evaluations, even when surgery is planned in the RH of a right-handed patient.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalNeurological Sciences
Issue number1
Publication statusPublished - Feb 2011


  • Crossed aphasia
  • Functional MRI
  • Hemispheric dominance
  • Language
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology


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