Accuracy of the ElastPQ® technique for the assessment of liver fibrosis in patients with chronic hepatitis C: A “real life” single center study

Giovanna Ferraioli, Laura Maiocchi, Raffaella Lissandrin, Carmine Tinelli, Annalisa De Silvestri, Carlo Filice, Elisabetta Above, Giorgio Barbarini, Raffaele Bruno, Silvia Corona, Carolina Dellafior, Marta Di Gregorio, Roberto Gulminetti, Paolo Lanzarini, Serena Ludovisi, Antonello Malfitano, Renato Maserati, Giuseppe Michelone, Lorenzo Minoli, Mario MondelliStefano Novati, Savino F A Patruno, Gianluigi Poma, Paolo Sacchi, Domenico Zanaboni, Liver Fibrosis Study Group

Research output: Contribution to journalArticlepeer-review


Background & Aims: Noninvasive assessment of liver stiffness has been increasingly used to evaluate fibrosis instead of liver biopsy, especially in patients with chronic viral hepatitis. The aim of this study was to assess the performance in staging liver fibrosis of the updated ElastPQ® technique (EPIQ7 ultrasound system, Philips Healthcare, Bothell, WA, USA) in the “real life” setting by using the FibroScan as the reference standard and to understand whether the use of the quality criteria improves the performance of the technique. Methods: This was a cross-sectional study: 278 patients affected by chronic hepatitis C referred for liver stiffness measurement with the FibroScan® 502 Touch device (Echosens, Paris, France) underwent measurements also with the ElastPQ® technique. For the assessment of significant fibrosis (F≥2), advanced fibrosis (F≥3) and cirrhosis (F=4), respectively, we used the cutoffs of 7.0, 9.5 and 12.0 kPa. The diagnostic performance of ElastPQ® was assessed using the area under the ROC (AUROC) curve analysis and was evaluated overall and for cases with (a) 10 measurements and IQR/M≤30%, (b) 5 measurements and IQR/M ≤30%, (c) 10 measurements and IQR/M>30%, (d) 5 measurements and IQR/M>30%. Results: The optimal cutoffs of ElastPQ® for significant fibrosis, advanced fibrosis and cirrhosis were 6.43, 9.54 and 11.34 kPa, respectively. For measurements with an IQR/M≤30%, there was no statistically significant decrease in sensitivity between 10 and 5 measurements (p=0.26, p=0.09, p=0.71, for F≥2, F≥3, and F=4, respectively). Conclusion: The ElastPQ® technique is reliable and accurate for staging liver fibrosis. The number of measurements does not affect the performance.

Original languageEnglish
Pages (from-to)331-335
Number of pages5
JournalJournal of Gastrointestinal and Liver Diseases
Issue number3
Publication statusPublished - Sep 1 2016


  • Chronic hepatitis C
  • Liver cirrhosis
  • Liver stiffness
  • Shear wave elastography
  • Transient elastography

ASJC Scopus subject areas

  • Gastroenterology


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