Abstract
Objective: To assess the accuracy of the traditional pH criterion for gastro-oesophageal reflux (i.e. fall of intra-oesophageal pH below 4) in a group of healthy volunteers. Design: Intra-oesophageal pH and motility of the pharynx, oesophageal body, lower oesophageal sphincter (Dentsleeve) and stomach were recorded in 19 healthy volunteers for a mean of 138 min (range 90-200 min) after a 700 Kcal mixed nutrient meal. Methods: The traditional pH criterion for gastro-oesophageal reflux was compared with a non-traditional one which was used as a standard. According to this criterion a reflux episode was an abrupt pH fall of ≥1 unit during a complete relaxation of the lower oesophageal sphincter and/or during a common cavity phenomenon. Results: The traditional criterion significantly (P <0.01) underscored reflux episodes by a mean of -1.2 episodes per volunteer with a 95% confidence interval (CI) from -1.6 to -0.8. The degree of inaccuracy varied little among the volunteers and a high correlation was found between number of reflux episodes per volunteer according to the two criteria (r = 0.95, P <0.001). Conclusions: The traditional criterion for gastro-oesophageal reflux underestimates the number of reflux episodes. However, the number of traditional reflux events seems to be a reliable index of the real number of reflux episodes, at least in our experimental conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 813-816 |
| Number of pages | 4 |
| Journal | European Journal of Gastroenterology and Hepatology |
| Volume | 4 |
| Issue number | 10 |
| Publication status | Published - 1992 |
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ASJC Scopus subject areas
- Gastroenterology
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Accuracy of the traditional pH criterion for gastro-oesophageal reflux. / Penagini, R.; Bartesaghi, B.; Bianchi, P. A.
In: European Journal of Gastroenterology and Hepatology, Vol. 4, No. 10, 1992, p. 813-816.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Accuracy of the traditional pH criterion for gastro-oesophageal reflux
AU - Penagini, R.
AU - Bartesaghi, B.
AU - Bianchi, P. A.
PY - 1992
Y1 - 1992
N2 - Objective: To assess the accuracy of the traditional pH criterion for gastro-oesophageal reflux (i.e. fall of intra-oesophageal pH below 4) in a group of healthy volunteers. Design: Intra-oesophageal pH and motility of the pharynx, oesophageal body, lower oesophageal sphincter (Dentsleeve) and stomach were recorded in 19 healthy volunteers for a mean of 138 min (range 90-200 min) after a 700 Kcal mixed nutrient meal. Methods: The traditional pH criterion for gastro-oesophageal reflux was compared with a non-traditional one which was used as a standard. According to this criterion a reflux episode was an abrupt pH fall of ≥1 unit during a complete relaxation of the lower oesophageal sphincter and/or during a common cavity phenomenon. Results: The traditional criterion significantly (P <0.01) underscored reflux episodes by a mean of -1.2 episodes per volunteer with a 95% confidence interval (CI) from -1.6 to -0.8. The degree of inaccuracy varied little among the volunteers and a high correlation was found between number of reflux episodes per volunteer according to the two criteria (r = 0.95, P <0.001). Conclusions: The traditional criterion for gastro-oesophageal reflux underestimates the number of reflux episodes. However, the number of traditional reflux events seems to be a reliable index of the real number of reflux episodes, at least in our experimental conditions.
AB - Objective: To assess the accuracy of the traditional pH criterion for gastro-oesophageal reflux (i.e. fall of intra-oesophageal pH below 4) in a group of healthy volunteers. Design: Intra-oesophageal pH and motility of the pharynx, oesophageal body, lower oesophageal sphincter (Dentsleeve) and stomach were recorded in 19 healthy volunteers for a mean of 138 min (range 90-200 min) after a 700 Kcal mixed nutrient meal. Methods: The traditional pH criterion for gastro-oesophageal reflux was compared with a non-traditional one which was used as a standard. According to this criterion a reflux episode was an abrupt pH fall of ≥1 unit during a complete relaxation of the lower oesophageal sphincter and/or during a common cavity phenomenon. Results: The traditional criterion significantly (P <0.01) underscored reflux episodes by a mean of -1.2 episodes per volunteer with a 95% confidence interval (CI) from -1.6 to -0.8. The degree of inaccuracy varied little among the volunteers and a high correlation was found between number of reflux episodes per volunteer according to the two criteria (r = 0.95, P <0.001). Conclusions: The traditional criterion for gastro-oesophageal reflux underestimates the number of reflux episodes. However, the number of traditional reflux events seems to be a reliable index of the real number of reflux episodes, at least in our experimental conditions.
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M3 - Article
AN - SCOPUS:0026785986
VL - 4
SP - 813
EP - 816
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
SN - 0954-691X
IS - 10
ER -