Accuracy of transvaginal sonography and contrast-enhanced magnetic resonance-colonography for the presurgical staging of deep infiltrating endometriosis

A. Vimercati, M. T. Achilarre, A. Scardapane, F. Lorusso, O. Ceci, G. Mangiatordi, G. Angelelli, B. Van Herendael, L. Selvaggi, S. Bettocchi

Research output: Contribution to journalArticle

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Abstract

ABSTRACT Objective To investigate the accuracy of transvaginal sonography (TVS) and contrast-enhanced magnetic resonance-colonography (CE-MR-C) for the presurgical assessment of deep infiltrating endometriosis (DIE). Methods Ninety women were enrolled prospectively for suspicion of DIE. All patients underwent TVS and CE-MR-C, with each operator blinded to the results of the other exam, before laparoscopy. The sites of DIE examined by both imaging techniques were: rectovaginal septum, pouch of Douglas, uterosacral ligaments, vesicouterine pouch, bowel, bladder and vagina. The presence of adhesions and the involvement of adnexa and of a previous abdominal scar, when there was clinical suspicion, were also evaluated. TVS and CEMR- C findings were compared with laparoscopic and histological results. Results Endometriosis was confirmed by laparoscopy in 95.6% (86/90) of cases. In 82.2% (74/90) of patients there was DIE. The global accuracy for TVS in the detection of DIE was 89.2%, sensitivity was 81.1%, specificity was 94.2%, positive predictive value was 89.6%, negative predictive value was 89.0%, the positive likelihood ratio was 13.9 and the negative likelihood ratio was 0.2. For CE-MR-C, these values were 87.2%, 71.1%, 97.1%, 93.7%, 84.6%, 24.4 and 0.3, respectively. CE-MR-C allowed diagnosis of all cases of bowel involvement; the accuracy for infiltration and stenosis was 100%. The accuracy of TVS for rectosigmoid nodules was 91.1% and that for infiltration was 88.9%. Conclusions Both TVS and CE-MR-C showed satisfactory results for the presurgical assessment of DIE. TVS appears to be a powerful, simple, feasible, cost-effective tool for preoperative staging of DIE. CE-MR-C is an .X-ray free' technique, which could be reserved for cases with deep infiltrating rectosigmoid lesions and for the prediction of stenosis and involvement of the upper part of the colon and small intestine.

Original languageEnglish
Pages (from-to)592-603
Number of pages12
JournalUltrasound in Obstetrics and Gynecology
Volume40
Issue number5
DOIs
Publication statusPublished - Nov 2012

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Endometriosis
Ultrasonography
Magnetic Resonance Spectroscopy
Laparoscopy
Pathologic Constriction
Douglas' Pouch
Vagina
Ligaments
Small Intestine
Cicatrix
Colon
Urinary Bladder
X-Rays
Costs and Cost Analysis

Keywords

  • Deep infiltrating endometriosis
  • Magnetic resonance imaging
  • Presurgical staging
  • Transvaginal sonography

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Reproductive Medicine
  • Medicine(all)

Cite this

Accuracy of transvaginal sonography and contrast-enhanced magnetic resonance-colonography for the presurgical staging of deep infiltrating endometriosis. / Vimercati, A.; Achilarre, M. T.; Scardapane, A.; Lorusso, F.; Ceci, O.; Mangiatordi, G.; Angelelli, G.; Van Herendael, B.; Selvaggi, L.; Bettocchi, S.

In: Ultrasound in Obstetrics and Gynecology, Vol. 40, No. 5, 11.2012, p. 592-603.

Research output: Contribution to journalArticle

Vimercati, A, Achilarre, MT, Scardapane, A, Lorusso, F, Ceci, O, Mangiatordi, G, Angelelli, G, Van Herendael, B, Selvaggi, L & Bettocchi, S 2012, 'Accuracy of transvaginal sonography and contrast-enhanced magnetic resonance-colonography for the presurgical staging of deep infiltrating endometriosis', Ultrasound in Obstetrics and Gynecology, vol. 40, no. 5, pp. 592-603. https://doi.org/10.1002/uog.11179
Vimercati, A. ; Achilarre, M. T. ; Scardapane, A. ; Lorusso, F. ; Ceci, O. ; Mangiatordi, G. ; Angelelli, G. ; Van Herendael, B. ; Selvaggi, L. ; Bettocchi, S. / Accuracy of transvaginal sonography and contrast-enhanced magnetic resonance-colonography for the presurgical staging of deep infiltrating endometriosis. In: Ultrasound in Obstetrics and Gynecology. 2012 ; Vol. 40, No. 5. pp. 592-603.
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abstract = "ABSTRACT Objective To investigate the accuracy of transvaginal sonography (TVS) and contrast-enhanced magnetic resonance-colonography (CE-MR-C) for the presurgical assessment of deep infiltrating endometriosis (DIE). Methods Ninety women were enrolled prospectively for suspicion of DIE. All patients underwent TVS and CE-MR-C, with each operator blinded to the results of the other exam, before laparoscopy. The sites of DIE examined by both imaging techniques were: rectovaginal septum, pouch of Douglas, uterosacral ligaments, vesicouterine pouch, bowel, bladder and vagina. The presence of adhesions and the involvement of adnexa and of a previous abdominal scar, when there was clinical suspicion, were also evaluated. TVS and CEMR- C findings were compared with laparoscopic and histological results. Results Endometriosis was confirmed by laparoscopy in 95.6{\%} (86/90) of cases. In 82.2{\%} (74/90) of patients there was DIE. The global accuracy for TVS in the detection of DIE was 89.2{\%}, sensitivity was 81.1{\%}, specificity was 94.2{\%}, positive predictive value was 89.6{\%}, negative predictive value was 89.0{\%}, the positive likelihood ratio was 13.9 and the negative likelihood ratio was 0.2. For CE-MR-C, these values were 87.2{\%}, 71.1{\%}, 97.1{\%}, 93.7{\%}, 84.6{\%}, 24.4 and 0.3, respectively. CE-MR-C allowed diagnosis of all cases of bowel involvement; the accuracy for infiltration and stenosis was 100{\%}. The accuracy of TVS for rectosigmoid nodules was 91.1{\%} and that for infiltration was 88.9{\%}. Conclusions Both TVS and CE-MR-C showed satisfactory results for the presurgical assessment of DIE. TVS appears to be a powerful, simple, feasible, cost-effective tool for preoperative staging of DIE. CE-MR-C is an .X-ray free' technique, which could be reserved for cases with deep infiltrating rectosigmoid lesions and for the prediction of stenosis and involvement of the upper part of the colon and small intestine.",
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AU - Vimercati, A.

AU - Achilarre, M. T.

AU - Scardapane, A.

AU - Lorusso, F.

AU - Ceci, O.

AU - Mangiatordi, G.

AU - Angelelli, G.

AU - Van Herendael, B.

AU - Selvaggi, L.

AU - Bettocchi, S.

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N2 - ABSTRACT Objective To investigate the accuracy of transvaginal sonography (TVS) and contrast-enhanced magnetic resonance-colonography (CE-MR-C) for the presurgical assessment of deep infiltrating endometriosis (DIE). Methods Ninety women were enrolled prospectively for suspicion of DIE. All patients underwent TVS and CE-MR-C, with each operator blinded to the results of the other exam, before laparoscopy. The sites of DIE examined by both imaging techniques were: rectovaginal septum, pouch of Douglas, uterosacral ligaments, vesicouterine pouch, bowel, bladder and vagina. The presence of adhesions and the involvement of adnexa and of a previous abdominal scar, when there was clinical suspicion, were also evaluated. TVS and CEMR- C findings were compared with laparoscopic and histological results. Results Endometriosis was confirmed by laparoscopy in 95.6% (86/90) of cases. In 82.2% (74/90) of patients there was DIE. The global accuracy for TVS in the detection of DIE was 89.2%, sensitivity was 81.1%, specificity was 94.2%, positive predictive value was 89.6%, negative predictive value was 89.0%, the positive likelihood ratio was 13.9 and the negative likelihood ratio was 0.2. For CE-MR-C, these values were 87.2%, 71.1%, 97.1%, 93.7%, 84.6%, 24.4 and 0.3, respectively. CE-MR-C allowed diagnosis of all cases of bowel involvement; the accuracy for infiltration and stenosis was 100%. The accuracy of TVS for rectosigmoid nodules was 91.1% and that for infiltration was 88.9%. Conclusions Both TVS and CE-MR-C showed satisfactory results for the presurgical assessment of DIE. TVS appears to be a powerful, simple, feasible, cost-effective tool for preoperative staging of DIE. CE-MR-C is an .X-ray free' technique, which could be reserved for cases with deep infiltrating rectosigmoid lesions and for the prediction of stenosis and involvement of the upper part of the colon and small intestine.

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KW - Magnetic resonance imaging

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