Accuracy of ultrasound imaging technique for assessing lipoatrophy in HIV-infected subjects

Giovanna Ferraioli, Carmine Tinelli, Luigia Scudeller, Gaetano Filice, Carlo Filice, Elisabetta Above, Serena Cima, Marta Di Gregorio, Rosario Gulizia, Roberto Gulminetti, Renato Maserati, Stefano Novati, Gianluigi Poma, Paolo Sacchi, Alessia Uglietti, Domenico Zanaboni, Marco Zaramella

Research output: Contribution to journalArticle

Abstract

Objective: To compare the accuracy of ultrasound imaging technique to that of clinical diagnosis in evaluating subcutaneous fat changes in HIV-infected subjects. Methods: HIV-uninfected control subjects (Group A), HIV-infected subjects with clinically assessed lipoatrophy (Group B), and HIV-infected subjects without clinical lipoatrophy (Group C) underwent ultrasound measurements of subcutaneous fat thickness at facial, brachial and thigh regions. ROC curve analyses were used to estimate ultrasound prediction accuracy and cut-off values of subcutaneous fat thickness. Results: 228 subjects were enrolled: 78 in Group A, 73 in Group B, and 77 in Group C. Facial lipoatrophy: ROC curve analysis identified optimal cut-off value of 13.3 mm [sensitivity, 96.0%; specificity, 76.9% AUC 0.92], 5.0 mm [sensitivity, 71.4%; specificity, 92.3%; AUC 0.90] and 11.2 mm [sensitivity, 95.8%; specificity, 89.7%; AUC 0.97] for females and 12.05 mm [sensitivity, 51.2%; specificity, 87.2%; AUC 0.74], 4.1 mm [sensitivity, 76.2%; specificity, 89.7%; AUC 0.85] and 4.35 mm [sensitivity, 60.0%; specificity, 89.7%; AUC 0.82] for males in assessing facial, brachial and crural lipoatrophy respectively. Using this cut-off values, 12/25 (48%) females and 17/49 (34.7%) males, 12/28 (42.9%) females and 23/49 (46.9%) males, 19/28 (67.9%) females and 12/49 (24.5%) males in Group C would be classified as "sub-clinical" facial, brachial and crural lipoatrophy respectively. Conclusions: The results of our study show that in the assessment of subtle subcutaneous fat changes ultrasound is more accurate than clinical evaluation and confirm the usefulness of ultrasound imaging technique in identifying lipoatrophy at an early stage.

Original languageEnglish
Pages (from-to)327-333
Number of pages7
JournalCurrent HIV Research
Volume9
Issue number5
DOIs
Publication statusPublished - 2011

Fingerprint

Area Under Curve
Ultrasonography
Subcutaneous Fat
HIV
ROC Curve
Arm
Leg
Thigh
Control Groups

Keywords

  • Accuracy studies
  • HIV
  • Lipodystrophy
  • Sensitivity and specificity
  • Ultrasound

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

@article{46a630608e3a4e30a0812e96b8abecef,
title = "Accuracy of ultrasound imaging technique for assessing lipoatrophy in HIV-infected subjects",
abstract = "Objective: To compare the accuracy of ultrasound imaging technique to that of clinical diagnosis in evaluating subcutaneous fat changes in HIV-infected subjects. Methods: HIV-uninfected control subjects (Group A), HIV-infected subjects with clinically assessed lipoatrophy (Group B), and HIV-infected subjects without clinical lipoatrophy (Group C) underwent ultrasound measurements of subcutaneous fat thickness at facial, brachial and thigh regions. ROC curve analyses were used to estimate ultrasound prediction accuracy and cut-off values of subcutaneous fat thickness. Results: 228 subjects were enrolled: 78 in Group A, 73 in Group B, and 77 in Group C. Facial lipoatrophy: ROC curve analysis identified optimal cut-off value of 13.3 mm [sensitivity, 96.0{\%}; specificity, 76.9{\%} AUC 0.92], 5.0 mm [sensitivity, 71.4{\%}; specificity, 92.3{\%}; AUC 0.90] and 11.2 mm [sensitivity, 95.8{\%}; specificity, 89.7{\%}; AUC 0.97] for females and 12.05 mm [sensitivity, 51.2{\%}; specificity, 87.2{\%}; AUC 0.74], 4.1 mm [sensitivity, 76.2{\%}; specificity, 89.7{\%}; AUC 0.85] and 4.35 mm [sensitivity, 60.0{\%}; specificity, 89.7{\%}; AUC 0.82] for males in assessing facial, brachial and crural lipoatrophy respectively. Using this cut-off values, 12/25 (48{\%}) females and 17/49 (34.7{\%}) males, 12/28 (42.9{\%}) females and 23/49 (46.9{\%}) males, 19/28 (67.9{\%}) females and 12/49 (24.5{\%}) males in Group C would be classified as {"}sub-clinical{"} facial, brachial and crural lipoatrophy respectively. Conclusions: The results of our study show that in the assessment of subtle subcutaneous fat changes ultrasound is more accurate than clinical evaluation and confirm the usefulness of ultrasound imaging technique in identifying lipoatrophy at an early stage.",
keywords = "Accuracy studies, HIV, Lipodystrophy, Sensitivity and specificity, Ultrasound",
author = "Giovanna Ferraioli and Carmine Tinelli and Luigia Scudeller and Gaetano Filice and Carlo Filice and Elisabetta Above and Serena Cima and {Di Gregorio}, Marta and Rosario Gulizia and Roberto Gulminetti and Renato Maserati and Stefano Novati and Gianluigi Poma and Paolo Sacchi and Alessia Uglietti and Domenico Zanaboni and Marco Zaramella",
year = "2011",
doi = "10.2174/157016211797635955",
language = "English",
volume = "9",
pages = "327--333",
journal = "Current HIV Research",
issn = "1570-162X",
publisher = "Bentham Science Publishers B.V.",
number = "5",

}

TY - JOUR

T1 - Accuracy of ultrasound imaging technique for assessing lipoatrophy in HIV-infected subjects

AU - Ferraioli, Giovanna

AU - Tinelli, Carmine

AU - Scudeller, Luigia

AU - Filice, Gaetano

AU - Filice, Carlo

AU - Above, Elisabetta

AU - Cima, Serena

AU - Di Gregorio, Marta

AU - Gulizia, Rosario

AU - Gulminetti, Roberto

AU - Maserati, Renato

AU - Novati, Stefano

AU - Poma, Gianluigi

AU - Sacchi, Paolo

AU - Uglietti, Alessia

AU - Zanaboni, Domenico

AU - Zaramella, Marco

PY - 2011

Y1 - 2011

N2 - Objective: To compare the accuracy of ultrasound imaging technique to that of clinical diagnosis in evaluating subcutaneous fat changes in HIV-infected subjects. Methods: HIV-uninfected control subjects (Group A), HIV-infected subjects with clinically assessed lipoatrophy (Group B), and HIV-infected subjects without clinical lipoatrophy (Group C) underwent ultrasound measurements of subcutaneous fat thickness at facial, brachial and thigh regions. ROC curve analyses were used to estimate ultrasound prediction accuracy and cut-off values of subcutaneous fat thickness. Results: 228 subjects were enrolled: 78 in Group A, 73 in Group B, and 77 in Group C. Facial lipoatrophy: ROC curve analysis identified optimal cut-off value of 13.3 mm [sensitivity, 96.0%; specificity, 76.9% AUC 0.92], 5.0 mm [sensitivity, 71.4%; specificity, 92.3%; AUC 0.90] and 11.2 mm [sensitivity, 95.8%; specificity, 89.7%; AUC 0.97] for females and 12.05 mm [sensitivity, 51.2%; specificity, 87.2%; AUC 0.74], 4.1 mm [sensitivity, 76.2%; specificity, 89.7%; AUC 0.85] and 4.35 mm [sensitivity, 60.0%; specificity, 89.7%; AUC 0.82] for males in assessing facial, brachial and crural lipoatrophy respectively. Using this cut-off values, 12/25 (48%) females and 17/49 (34.7%) males, 12/28 (42.9%) females and 23/49 (46.9%) males, 19/28 (67.9%) females and 12/49 (24.5%) males in Group C would be classified as "sub-clinical" facial, brachial and crural lipoatrophy respectively. Conclusions: The results of our study show that in the assessment of subtle subcutaneous fat changes ultrasound is more accurate than clinical evaluation and confirm the usefulness of ultrasound imaging technique in identifying lipoatrophy at an early stage.

AB - Objective: To compare the accuracy of ultrasound imaging technique to that of clinical diagnosis in evaluating subcutaneous fat changes in HIV-infected subjects. Methods: HIV-uninfected control subjects (Group A), HIV-infected subjects with clinically assessed lipoatrophy (Group B), and HIV-infected subjects without clinical lipoatrophy (Group C) underwent ultrasound measurements of subcutaneous fat thickness at facial, brachial and thigh regions. ROC curve analyses were used to estimate ultrasound prediction accuracy and cut-off values of subcutaneous fat thickness. Results: 228 subjects were enrolled: 78 in Group A, 73 in Group B, and 77 in Group C. Facial lipoatrophy: ROC curve analysis identified optimal cut-off value of 13.3 mm [sensitivity, 96.0%; specificity, 76.9% AUC 0.92], 5.0 mm [sensitivity, 71.4%; specificity, 92.3%; AUC 0.90] and 11.2 mm [sensitivity, 95.8%; specificity, 89.7%; AUC 0.97] for females and 12.05 mm [sensitivity, 51.2%; specificity, 87.2%; AUC 0.74], 4.1 mm [sensitivity, 76.2%; specificity, 89.7%; AUC 0.85] and 4.35 mm [sensitivity, 60.0%; specificity, 89.7%; AUC 0.82] for males in assessing facial, brachial and crural lipoatrophy respectively. Using this cut-off values, 12/25 (48%) females and 17/49 (34.7%) males, 12/28 (42.9%) females and 23/49 (46.9%) males, 19/28 (67.9%) females and 12/49 (24.5%) males in Group C would be classified as "sub-clinical" facial, brachial and crural lipoatrophy respectively. Conclusions: The results of our study show that in the assessment of subtle subcutaneous fat changes ultrasound is more accurate than clinical evaluation and confirm the usefulness of ultrasound imaging technique in identifying lipoatrophy at an early stage.

KW - Accuracy studies

KW - HIV

KW - Lipodystrophy

KW - Sensitivity and specificity

KW - Ultrasound

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