Accuracy of water-enema multidetector computed tomography (WE-MDCT) in colon cancer staging

a prospective study

E. Sibileau, Catherine Ridereau-Zins, D. Vanel, A. H. Pavageau, S. Bertrais, E. Metivier-Cesbron, A. Venara, C. Aubé

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose: To assess the accuracy of water-enema multidetector computed tomography (WE-MDCT) in extra-rectal colon cancer staging.

Materials and methods: Fifty-three patients (mean age 70 years) with extra-rectal colon cancer proven by colonoscopy and biopsy were prospectively evaluated by preoperative WE-MDCT. CT scans were both intraluminal (water enema or WE) and intravenous (iodinated) contrast enhanced (CE). All patients underwent surgery. Tumors were classified with the TNM staging system. Noted CT features were: tumor size and location; tumor form and edges; spread to the pericolic fat or neighboring organs; thickening of retroperitoneal fascia; number, size, and enhancement of the peritumoral lymph nodes. Tumors were classified on CT into 3 T-stage groups: T1/T2, T3, and T4. Lymph nodes were classified by their density after injection [positive over 100 Hounsfield units (HU)].

Results: Tumor localization to the specific colon segment was correct in all the cases. The agreement between WE-MDCT staging and histopathology staging was good (k = 0.64). An irregular and bowl-shaped aspect of the external edges of tumor provided excellent sensitivity for T3/T4 inclusion (Se 97.7%, NPV 85.7%). Thickening of a fascia or the abdominal wall provided good specificity for T4 stage (Sp 88.1%, NPV 94.9%). Enhancement over 100 HU of at least one peritumoral lymph node was the best criterion of N+ staging (Sp 67.7%, NPV 87.5%).

Conclusion: WE-MDCT permits good staging of colon cancer based on objective features.

Original languageEnglish
Pages (from-to)941-948
Number of pages8
JournalAbdominal Imaging
Volume39
Issue number5
DOIs
Publication statusPublished - 2014

Fingerprint

Multidetector Computed Tomography
Neoplasm Staging
Enema
Colonic Neoplasms
Prospective Studies
Water
Neoplasms
Lymph Nodes
Fascia
Rectal Neoplasms
Abdominal Wall
Colonoscopy
Colon
Fats
Biopsy
Injections

Keywords

  • Colon cancer
  • Tumoral staging
  • WE-MDCT

ASJC Scopus subject areas

  • Gastroenterology
  • Urology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

Cite this

Sibileau, E., Ridereau-Zins, C., Vanel, D., Pavageau, A. H., Bertrais, S., Metivier-Cesbron, E., ... Aubé, C. (2014). Accuracy of water-enema multidetector computed tomography (WE-MDCT) in colon cancer staging: a prospective study. Abdominal Imaging, 39(5), 941-948. https://doi.org/10.1007/s00261-014-0150-9

Accuracy of water-enema multidetector computed tomography (WE-MDCT) in colon cancer staging : a prospective study. / Sibileau, E.; Ridereau-Zins, Catherine; Vanel, D.; Pavageau, A. H.; Bertrais, S.; Metivier-Cesbron, E.; Venara, A.; Aubé, C.

In: Abdominal Imaging, Vol. 39, No. 5, 2014, p. 941-948.

Research output: Contribution to journalArticle

Sibileau, E, Ridereau-Zins, C, Vanel, D, Pavageau, AH, Bertrais, S, Metivier-Cesbron, E, Venara, A & Aubé, C 2014, 'Accuracy of water-enema multidetector computed tomography (WE-MDCT) in colon cancer staging: a prospective study', Abdominal Imaging, vol. 39, no. 5, pp. 941-948. https://doi.org/10.1007/s00261-014-0150-9
Sibileau, E. ; Ridereau-Zins, Catherine ; Vanel, D. ; Pavageau, A. H. ; Bertrais, S. ; Metivier-Cesbron, E. ; Venara, A. ; Aubé, C. / Accuracy of water-enema multidetector computed tomography (WE-MDCT) in colon cancer staging : a prospective study. In: Abdominal Imaging. 2014 ; Vol. 39, No. 5. pp. 941-948.
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abstract = "Purpose: To assess the accuracy of water-enema multidetector computed tomography (WE-MDCT) in extra-rectal colon cancer staging.Materials and methods: Fifty-three patients (mean age 70 years) with extra-rectal colon cancer proven by colonoscopy and biopsy were prospectively evaluated by preoperative WE-MDCT. CT scans were both intraluminal (water enema or WE) and intravenous (iodinated) contrast enhanced (CE). All patients underwent surgery. Tumors were classified with the TNM staging system. Noted CT features were: tumor size and location; tumor form and edges; spread to the pericolic fat or neighboring organs; thickening of retroperitoneal fascia; number, size, and enhancement of the peritumoral lymph nodes. Tumors were classified on CT into 3 T-stage groups: T1/T2, T3, and T4. Lymph nodes were classified by their density after injection [positive over 100 Hounsfield units (HU)].Results: Tumor localization to the specific colon segment was correct in all the cases. The agreement between WE-MDCT staging and histopathology staging was good (k = 0.64). An irregular and bowl-shaped aspect of the external edges of tumor provided excellent sensitivity for T3/T4 inclusion (Se 97.7{\%}, NPV 85.7{\%}). Thickening of a fascia or the abdominal wall provided good specificity for T4 stage (Sp 88.1{\%}, NPV 94.9{\%}). Enhancement over 100 HU of at least one peritumoral lymph node was the best criterion of N+ staging (Sp 67.7{\%}, NPV 87.5{\%}).Conclusion: WE-MDCT permits good staging of colon cancer based on objective features.",
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AU - Pavageau, A. H.

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AU - Venara, A.

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N2 - Purpose: To assess the accuracy of water-enema multidetector computed tomography (WE-MDCT) in extra-rectal colon cancer staging.Materials and methods: Fifty-three patients (mean age 70 years) with extra-rectal colon cancer proven by colonoscopy and biopsy were prospectively evaluated by preoperative WE-MDCT. CT scans were both intraluminal (water enema or WE) and intravenous (iodinated) contrast enhanced (CE). All patients underwent surgery. Tumors were classified with the TNM staging system. Noted CT features were: tumor size and location; tumor form and edges; spread to the pericolic fat or neighboring organs; thickening of retroperitoneal fascia; number, size, and enhancement of the peritumoral lymph nodes. Tumors were classified on CT into 3 T-stage groups: T1/T2, T3, and T4. Lymph nodes were classified by their density after injection [positive over 100 Hounsfield units (HU)].Results: Tumor localization to the specific colon segment was correct in all the cases. The agreement between WE-MDCT staging and histopathology staging was good (k = 0.64). An irregular and bowl-shaped aspect of the external edges of tumor provided excellent sensitivity for T3/T4 inclusion (Se 97.7%, NPV 85.7%). Thickening of a fascia or the abdominal wall provided good specificity for T4 stage (Sp 88.1%, NPV 94.9%). Enhancement over 100 HU of at least one peritumoral lymph node was the best criterion of N+ staging (Sp 67.7%, NPV 87.5%).Conclusion: WE-MDCT permits good staging of colon cancer based on objective features.

AB - Purpose: To assess the accuracy of water-enema multidetector computed tomography (WE-MDCT) in extra-rectal colon cancer staging.Materials and methods: Fifty-three patients (mean age 70 years) with extra-rectal colon cancer proven by colonoscopy and biopsy were prospectively evaluated by preoperative WE-MDCT. CT scans were both intraluminal (water enema or WE) and intravenous (iodinated) contrast enhanced (CE). All patients underwent surgery. Tumors were classified with the TNM staging system. Noted CT features were: tumor size and location; tumor form and edges; spread to the pericolic fat or neighboring organs; thickening of retroperitoneal fascia; number, size, and enhancement of the peritumoral lymph nodes. Tumors were classified on CT into 3 T-stage groups: T1/T2, T3, and T4. Lymph nodes were classified by their density after injection [positive over 100 Hounsfield units (HU)].Results: Tumor localization to the specific colon segment was correct in all the cases. The agreement between WE-MDCT staging and histopathology staging was good (k = 0.64). An irregular and bowl-shaped aspect of the external edges of tumor provided excellent sensitivity for T3/T4 inclusion (Se 97.7%, NPV 85.7%). Thickening of a fascia or the abdominal wall provided good specificity for T4 stage (Sp 88.1%, NPV 94.9%). Enhancement over 100 HU of at least one peritumoral lymph node was the best criterion of N+ staging (Sp 67.7%, NPV 87.5%).Conclusion: WE-MDCT permits good staging of colon cancer based on objective features.

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