TY - JOUR
T1 - Accuracy of whole-body MRI in the assessment of splenic involvement in lymphoma
AU - Littooij, Annemieke S.
AU - Kwee, Thomas C.
AU - Barber, Ignasi
AU - Granata, Claudio
AU - De Keizer, Bart
AU - Beek, Frederik J A
AU - Hobbelink, Monique G.
AU - Fijnheer, Rob
AU - Stoker, Jaap
AU - Nievelstein, Rutger A J
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Background: Accurate evaluation of the spleen is an important component of staging lymphoma, because this may have prognostic and therapeutic implications. Purpose: To determine the diagnostic value of whole-body magnetic resonance imaging (MRI), including diffusionweighted imaging (whole-body MRI-DWI) in the detection of splenic involvement in lymphoma. Material and Methods: This IRB approved, prospective multicenter study included a total of 107 patients with newly diagnosed, histologically proven lymphoma who underwent 1.5 Twhole-body MRI-DWI and FDG-PET/CT. Whole-body MRI-DWI and FDG-PET/CTwere independently evaluated by a radiologist and a nuclear medicine physician, in a blinded manner. Splenic involvement at MRI was defined as splenic index >725 cm3 or discrete nodules. At FDG-PET/CT splenic involvement was defined as splenic uptake greater than liver uptake or hypodense nodules at contrast-enhanced CT. FDG-PET/CT augmented with follow-up imaging after treatment was used as reference standard. Results: Splenic involvement was detected with FDG-PET/CT in 21 patients, all demonstrating response to treatment. The sensitivity, specificity, positive predictive value, and negative predictive value of whole-body MRI-DWI for the detection of splenic involvement were 85.7 %, 96.5 %, 85.7%, and 96.5%, respectively. Three out of six discrepancies were related to suboptimal criterion of splenic size used with whole-body MRI-DWI versus the size-independent FDG uptake. Conclusion: Whole-body MRI-DWI is reasonably accurate in the detection of splenic lymphomatous involvement.
AB - Background: Accurate evaluation of the spleen is an important component of staging lymphoma, because this may have prognostic and therapeutic implications. Purpose: To determine the diagnostic value of whole-body magnetic resonance imaging (MRI), including diffusionweighted imaging (whole-body MRI-DWI) in the detection of splenic involvement in lymphoma. Material and Methods: This IRB approved, prospective multicenter study included a total of 107 patients with newly diagnosed, histologically proven lymphoma who underwent 1.5 Twhole-body MRI-DWI and FDG-PET/CT. Whole-body MRI-DWI and FDG-PET/CTwere independently evaluated by a radiologist and a nuclear medicine physician, in a blinded manner. Splenic involvement at MRI was defined as splenic index >725 cm3 or discrete nodules. At FDG-PET/CT splenic involvement was defined as splenic uptake greater than liver uptake or hypodense nodules at contrast-enhanced CT. FDG-PET/CT augmented with follow-up imaging after treatment was used as reference standard. Results: Splenic involvement was detected with FDG-PET/CT in 21 patients, all demonstrating response to treatment. The sensitivity, specificity, positive predictive value, and negative predictive value of whole-body MRI-DWI for the detection of splenic involvement were 85.7 %, 96.5 %, 85.7%, and 96.5%, respectively. Three out of six discrepancies were related to suboptimal criterion of splenic size used with whole-body MRI-DWI versus the size-independent FDG uptake. Conclusion: Whole-body MRI-DWI is reasonably accurate in the detection of splenic lymphomatous involvement.
KW - Diffusion-weighted imaging
KW - FDG PET/CT
KW - Lymphoma
KW - Magnetic resonance imaging (MRI)
KW - Splenic involvement
KW - Whole-body MRI
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U2 - 10.1177/0284185115571657
DO - 10.1177/0284185115571657
M3 - Article
C2 - 25681490
AN - SCOPUS:84961774938
VL - 57
SP - 142
EP - 151
JO - Acta Radiologica
JF - Acta Radiologica
SN - 0284-1851
IS - 2
ER -