ACE DD genotype: A predisposing factor for abdominal aortic aneurysm

C. Fatini, Giovanni Pratesi, F. Sofi, F. Gensini, E. Sticchi, B. Lari, R. Pulli, W. Dorigo, L. Azas, C. Pratesi, G. F. Gensini, R. Abbate

Research output: Contribution to journalArticle

Abstract

Objective. To examine the role of polymorphisms in angiotensin converting enzyme (ACE, I/D) and angiotensin II receptor (AT1R, A1166C) in the development of abdominal aortic aneurysm (AAA). Materials and methods. We investigated 250 consecutive patients, 217 males and 33 females (median age 72, range 50-83), undergone AAA elective repair and 250 healthy controls, comparable for sex and age. ACE and AT1R polymorphisms were studied by PCR-RFLP analysis. The genotype distribution was in Hardy-Weinberg equilibrium for all polymorphisms. Results: The genotype distribution and allele frequency of ACE I/D, but not AT1R A1166C polymorphism were significantly different between patients and controls (ACE I/D: p=0.0002 and p

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume29
Issue number3
DOIs
Publication statusPublished - Mar 2005

Keywords

  • Abdominal aortic aneurysm
  • ACE polymorphisms
  • Genetic risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

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    Fatini, C., Pratesi, G., Sofi, F., Gensini, F., Sticchi, E., Lari, B., Pulli, R., Dorigo, W., Azas, L., Pratesi, C., Gensini, G. F., & Abbate, R. (2005). ACE DD genotype: A predisposing factor for abdominal aortic aneurysm. European Journal of Vascular and Endovascular Surgery, 29(3), 227-232. https://doi.org/10.1016/j.ejvs.2004.12.018