ACE inhibition attenuates sympathetic coronary vasoconstriction in patients with coronary artery disease

R. Perondi, A. Saino, R. A. Tio, G. Pomidossi, L. Gregorini, P. Alessio, A. Morganti, A. Zanchetti, G. Mancia

Research output: Contribution to journalArticle

Abstract

Background. In humans, angiotensin converting enzyme (ACE) inhibition attenuates the vasoconstriction induced by sympathetic stimulation in a number of peripheral districts. Whether this is also the case in the coronary circulation is unknown, however. Methods and Results. In nine normotensive patients with angiographically assessed coronary atherosclerosis, we measured the changes in mean arterial pressure (intra-arterial catheter), heart rate, rate-pressure product (RPP), coronary sinus blood flow (CBF, thermodilution method), and coronary vascular resistance (CVR, ratio between mean arterial pressure and CBF) induced by the cold pressor test (CPT, 2 minutes) and diving (30 seconds), i.e., two stimuli eliciting a sympathetic coronary vasoconstriction. The measurements were performed in the control condition and 30 minutes after captopril 25 mg p.o. In the control condition, CPT caused an increase in mean arterial pressure and heart rate. Despite the increase in RPP (+20.7±3.2%, p

Original languageEnglish
Pages (from-to)2004-2013
Number of pages10
JournalCirculation
Volume85
Issue number6
Publication statusPublished - 1992

Keywords

  • angiotensin converting enzyme
  • diving
  • heart disease, ischemic

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Perondi, R., Saino, A., Tio, R. A., Pomidossi, G., Gregorini, L., Alessio, P., Morganti, A., Zanchetti, A., & Mancia, G. (1992). ACE inhibition attenuates sympathetic coronary vasoconstriction in patients with coronary artery disease. Circulation, 85(6), 2004-2013.