ACE inhibition attenuates sympathetic coronary vasoconstriction in patients with coronary artery disease

R. Perondi, A. Saino, R. A. Tio, G. Pomidossi, L. Gregorini, P. Alessio, A. Morganti, A. Zanchetti, G. Mancia

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Background. In humans, angiotensin converting enzyme (ACE) inhibition attenuates the vasoconstriction induced by sympathetic stimulation in a number of peripheral districts. Whether this is also the case in the coronary circulation is unknown, however. Methods and Results. In nine normotensive patients with angiographically assessed coronary atherosclerosis, we measured the changes in mean arterial pressure (intra-arterial catheter), heart rate, rate-pressure product (RPP), coronary sinus blood flow (CBF, thermodilution method), and coronary vascular resistance (CVR, ratio between mean arterial pressure and CBF) induced by the cold pressor test (CPT, 2 minutes) and diving (30 seconds), i.e., two stimuli eliciting a sympathetic coronary vasoconstriction. The measurements were performed in the control condition and 30 minutes after captopril 25 mg p.o. In the control condition, CPT caused an increase in mean arterial pressure and heart rate. Despite the increase in RPP (+20.7±3.2%, p

Original languageEnglish
Pages (from-to)2004-2013
Number of pages10
JournalCirculation
Volume85
Issue number6
Publication statusPublished - 1992

Fingerprint

Peptidyl-Dipeptidase A
Vasoconstriction
Coronary Artery Disease
Arterial Pressure
Heart Rate
Pressure
Thermodilution
Coronary Circulation
Diving
Coronary Sinus
Captopril
Vascular Resistance
Catheters

Keywords

  • angiotensin converting enzyme
  • diving
  • heart disease, ischemic

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Perondi, R., Saino, A., Tio, R. A., Pomidossi, G., Gregorini, L., Alessio, P., ... Mancia, G. (1992). ACE inhibition attenuates sympathetic coronary vasoconstriction in patients with coronary artery disease. Circulation, 85(6), 2004-2013.

ACE inhibition attenuates sympathetic coronary vasoconstriction in patients with coronary artery disease. / Perondi, R.; Saino, A.; Tio, R. A.; Pomidossi, G.; Gregorini, L.; Alessio, P.; Morganti, A.; Zanchetti, A.; Mancia, G.

In: Circulation, Vol. 85, No. 6, 1992, p. 2004-2013.

Research output: Contribution to journalArticle

Perondi, R, Saino, A, Tio, RA, Pomidossi, G, Gregorini, L, Alessio, P, Morganti, A, Zanchetti, A & Mancia, G 1992, 'ACE inhibition attenuates sympathetic coronary vasoconstriction in patients with coronary artery disease', Circulation, vol. 85, no. 6, pp. 2004-2013.
Perondi R, Saino A, Tio RA, Pomidossi G, Gregorini L, Alessio P et al. ACE inhibition attenuates sympathetic coronary vasoconstriction in patients with coronary artery disease. Circulation. 1992;85(6):2004-2013.
Perondi, R. ; Saino, A. ; Tio, R. A. ; Pomidossi, G. ; Gregorini, L. ; Alessio, P. ; Morganti, A. ; Zanchetti, A. ; Mancia, G. / ACE inhibition attenuates sympathetic coronary vasoconstriction in patients with coronary artery disease. In: Circulation. 1992 ; Vol. 85, No. 6. pp. 2004-2013.
@article{28399bb459d74433a4fe4a8870a81cf5,
title = "ACE inhibition attenuates sympathetic coronary vasoconstriction in patients with coronary artery disease",
abstract = "Background. In humans, angiotensin converting enzyme (ACE) inhibition attenuates the vasoconstriction induced by sympathetic stimulation in a number of peripheral districts. Whether this is also the case in the coronary circulation is unknown, however. Methods and Results. In nine normotensive patients with angiographically assessed coronary atherosclerosis, we measured the changes in mean arterial pressure (intra-arterial catheter), heart rate, rate-pressure product (RPP), coronary sinus blood flow (CBF, thermodilution method), and coronary vascular resistance (CVR, ratio between mean arterial pressure and CBF) induced by the cold pressor test (CPT, 2 minutes) and diving (30 seconds), i.e., two stimuli eliciting a sympathetic coronary vasoconstriction. The measurements were performed in the control condition and 30 minutes after captopril 25 mg p.o. In the control condition, CPT caused an increase in mean arterial pressure and heart rate. Despite the increase in RPP (+20.7±3.2{\%}, p",
keywords = "angiotensin converting enzyme, diving, heart disease, ischemic",
author = "R. Perondi and A. Saino and Tio, {R. A.} and G. Pomidossi and L. Gregorini and P. Alessio and A. Morganti and A. Zanchetti and G. Mancia",
year = "1992",
language = "English",
volume = "85",
pages = "2004--2013",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - ACE inhibition attenuates sympathetic coronary vasoconstriction in patients with coronary artery disease

AU - Perondi, R.

AU - Saino, A.

AU - Tio, R. A.

AU - Pomidossi, G.

AU - Gregorini, L.

AU - Alessio, P.

AU - Morganti, A.

AU - Zanchetti, A.

AU - Mancia, G.

PY - 1992

Y1 - 1992

N2 - Background. In humans, angiotensin converting enzyme (ACE) inhibition attenuates the vasoconstriction induced by sympathetic stimulation in a number of peripheral districts. Whether this is also the case in the coronary circulation is unknown, however. Methods and Results. In nine normotensive patients with angiographically assessed coronary atherosclerosis, we measured the changes in mean arterial pressure (intra-arterial catheter), heart rate, rate-pressure product (RPP), coronary sinus blood flow (CBF, thermodilution method), and coronary vascular resistance (CVR, ratio between mean arterial pressure and CBF) induced by the cold pressor test (CPT, 2 minutes) and diving (30 seconds), i.e., two stimuli eliciting a sympathetic coronary vasoconstriction. The measurements were performed in the control condition and 30 minutes after captopril 25 mg p.o. In the control condition, CPT caused an increase in mean arterial pressure and heart rate. Despite the increase in RPP (+20.7±3.2%, p

AB - Background. In humans, angiotensin converting enzyme (ACE) inhibition attenuates the vasoconstriction induced by sympathetic stimulation in a number of peripheral districts. Whether this is also the case in the coronary circulation is unknown, however. Methods and Results. In nine normotensive patients with angiographically assessed coronary atherosclerosis, we measured the changes in mean arterial pressure (intra-arterial catheter), heart rate, rate-pressure product (RPP), coronary sinus blood flow (CBF, thermodilution method), and coronary vascular resistance (CVR, ratio between mean arterial pressure and CBF) induced by the cold pressor test (CPT, 2 minutes) and diving (30 seconds), i.e., two stimuli eliciting a sympathetic coronary vasoconstriction. The measurements were performed in the control condition and 30 minutes after captopril 25 mg p.o. In the control condition, CPT caused an increase in mean arterial pressure and heart rate. Despite the increase in RPP (+20.7±3.2%, p

KW - angiotensin converting enzyme

KW - diving

KW - heart disease, ischemic

UR - http://www.scopus.com/inward/record.url?scp=0026740717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026740717&partnerID=8YFLogxK

M3 - Article

VL - 85

SP - 2004

EP - 2013

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 6

ER -