Ace inhibition may influence exercise-Induced changes in fibrinolysis

R. Paniccia; D. Frisco; B. Bandinelli; G. Pacenti; A. Colella; M. Comeglio; R. Abbate; G. F. Gensini; G. G. Neri Serneri

Ace inhibition may influence exercise-Induced changes in fibrinolysis

R. Paniccia, D. Frisco, B. Bandinelli, G. Pacenti, A. Colella, M. Comeglio, R. Abbate, G. F. Gensini, G. G. Neri Serneri

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Renin-angiotensin system has been reported to regulate plasminogen activation and fibrinolysis and ACE inhibitors could play a role in the modulation of fibrinolytic system. The present study was planned to investigate the effect ot short-term ACE inhibition on fibrinolysis both in baseline conditions and after physical exercise. Ten healthy non-smoker males (25 to 40 yrs) received placebo or enalapril (20 mg) once daily for a 7-day treatment period with a wash-out intermediate period of 15 days. Before and after each treatment period the subjects underwent a treadmill stress test according to a modified Bruce protocol. Blood samples were taken in the morning before and after maximal exercise. The following fibrinolytic parameters were measured: a) euglobulin lysis time (ELT), b) t-PA activity and antigen plasma levels (t-PA act and t-PA ag. Biopool), c) PA1-1 activity and antigen (PAI-1 act and PAI-1 ag, Biopool) and d) plasminogen activity (Behring). After enalapril the exercise-induced decrease in ELT (p

Original language	English
Pages (from-to)	102
Number of pages	1
Journal	Fibrinolysis
Volume	10
Issue number	SUPPL. 3
Publication status	Published - 1996

ASJC Scopus subject areas

Hematology

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title = "Ace inhibition may influence exercise-Induced changes in fibrinolysis",

abstract = "Renin-angiotensin system has been reported to regulate plasminogen activation and fibrinolysis and ACE inhibitors could play a role in the modulation of fibrinolytic system. The present study was planned to investigate the effect ot short-term ACE inhibition on fibrinolysis both in baseline conditions and after physical exercise. Ten healthy non-smoker males (25 to 40 yrs) received placebo or enalapril (20 mg) once daily for a 7-day treatment period with a wash-out intermediate period of 15 days. Before and after each treatment period the subjects underwent a treadmill stress test according to a modified Bruce protocol. Blood samples were taken in the morning before and after maximal exercise. The following fibrinolytic parameters were measured: a) euglobulin lysis time (ELT), b) t-PA activity and antigen plasma levels (t-PA act and t-PA ag. Biopool), c) PA1-1 activity and antigen (PAI-1 act and PAI-1 ag, Biopool) and d) plasminogen activity (Behring). After enalapril the exercise-induced decrease in ELT (p",

author = "R. Paniccia and D. Frisco and B. Bandinelli and G. Pacenti and A. Colella and M. Comeglio and R. Abbate and Gensini, {G. F.} and {Neri Serneri}, {G. G.}",

year = "1996",

language = "English",

volume = "10",

pages = "102",

journal = "Fibrinolysis and Proteolysis",

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T1 - Ace inhibition may influence exercise-Induced changes in fibrinolysis

AU - Paniccia, R.

AU - Frisco, D.

AU - Bandinelli, B.

AU - Pacenti, G.

AU - Colella, A.

AU - Comeglio, M.

AU - Abbate, R.

AU - Gensini, G. F.

AU - Neri Serneri, G. G.

PY - 1996

Y1 - 1996

N2 - Renin-angiotensin system has been reported to regulate plasminogen activation and fibrinolysis and ACE inhibitors could play a role in the modulation of fibrinolytic system. The present study was planned to investigate the effect ot short-term ACE inhibition on fibrinolysis both in baseline conditions and after physical exercise. Ten healthy non-smoker males (25 to 40 yrs) received placebo or enalapril (20 mg) once daily for a 7-day treatment period with a wash-out intermediate period of 15 days. Before and after each treatment period the subjects underwent a treadmill stress test according to a modified Bruce protocol. Blood samples were taken in the morning before and after maximal exercise. The following fibrinolytic parameters were measured: a) euglobulin lysis time (ELT), b) t-PA activity and antigen plasma levels (t-PA act and t-PA ag. Biopool), c) PA1-1 activity and antigen (PAI-1 act and PAI-1 ag, Biopool) and d) plasminogen activity (Behring). After enalapril the exercise-induced decrease in ELT (p

AB - Renin-angiotensin system has been reported to regulate plasminogen activation and fibrinolysis and ACE inhibitors could play a role in the modulation of fibrinolytic system. The present study was planned to investigate the effect ot short-term ACE inhibition on fibrinolysis both in baseline conditions and after physical exercise. Ten healthy non-smoker males (25 to 40 yrs) received placebo or enalapril (20 mg) once daily for a 7-day treatment period with a wash-out intermediate period of 15 days. Before and after each treatment period the subjects underwent a treadmill stress test according to a modified Bruce protocol. Blood samples were taken in the morning before and after maximal exercise. The following fibrinolytic parameters were measured: a) euglobulin lysis time (ELT), b) t-PA activity and antigen plasma levels (t-PA act and t-PA ag. Biopool), c) PA1-1 activity and antigen (PAI-1 act and PAI-1 ag, Biopool) and d) plasminogen activity (Behring). After enalapril the exercise-induced decrease in ELT (p

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M3 - Article

AN - SCOPUS:33846668557

VL - 10

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JO - Fibrinolysis and Proteolysis

JF - Fibrinolysis and Proteolysis

SN - 1369-0191

IS - SUPPL. 3

ER -

Ace inhibition may influence exercise-Induced changes in fibrinolysis

Abstract

ASJC Scopus subject areas

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