Ace inhibition may influence exercise-Induced changes in fibrinolysis

R. Paniccia, D. Frisco, B. Bandinelli, G. Pacenti, A. Colella, M. Comeglio, R. Abbate, G. F. Gensini, G. G. Neri Serneri

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Abstract

Renin-angiotensin system has been reported to regulate plasminogen activation and fibrinolysis and ACE inhibitors could play a role in the modulation of fibrinolytic system. The present study was planned to investigate the effect ot short-term ACE inhibition on fibrinolysis both in baseline conditions and after physical exercise. Ten healthy non-smoker males (25 to 40 yrs) received placebo or enalapril (20 mg) once daily for a 7-day treatment period with a wash-out intermediate period of 15 days. Before and after each treatment period the subjects underwent a treadmill stress test according to a modified Bruce protocol. Blood samples were taken in the morning before and after maximal exercise. The following fibrinolytic parameters were measured: a) euglobulin lysis time (ELT), b) t-PA activity and antigen plasma levels (t-PA act and t-PA ag. Biopool), c) PA1-1 activity and antigen (PAI-1 act and PAI-1 ag, Biopool) and d) plasminogen activity (Behring). After enalapril the exercise-induced decrease in ELT (p

Original languageEnglish
Pages (from-to)102
Number of pages1
JournalFibrinolysis
Volume10
Issue numberSUPPL. 3
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Hematology

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