Abstract
Renin-angiotensin system has been reported to regulate plasminogen activation and fibrinolysis and ACE inhibitors could play a role in the modulation of fibrinolytic system. The present study was planned to investigate the effect ot short-term ACE inhibition on fibrinolysis both in baseline conditions and after physical exercise. Ten healthy non-smoker males (25 to 40 yrs) received placebo or enalapril (20 mg) once daily for a 7-day treatment period with a wash-out intermediate period of 15 days. Before and after each treatment period the subjects underwent a treadmill stress test according to a modified Bruce protocol. Blood samples were taken in the morning before and after maximal exercise. The following fibrinolytic parameters were measured: a) euglobulin lysis time (ELT), b) t-PA activity and antigen plasma levels (t-PA act and t-PA ag. Biopool), c) PA1-1 activity and antigen (PAI-1 act and PAI-1 ag, Biopool) and d) plasminogen activity (Behring). After enalapril the exercise-induced decrease in ELT (p
Original language | English |
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Pages (from-to) | 102 |
Number of pages | 1 |
Journal | Fibrinolysis |
Volume | 10 |
Issue number | SUPPL. 3 |
Publication status | Published - 1996 |
ASJC Scopus subject areas
- Hematology