ACE inhibitors can induce circulating antibodies directed to antigens of the superficial epidermal cells

Emanuele Cozzani, Gian Marco Rosa, Massimo Drosera, Chiara Intra, Antonio Barsotti, Aurora Parodi

Research output: Contribution to journalArticle

Abstract

Drug-induced pemphigus has been reported in patients receiving angiotensin-converting enzyme inhibitors. The aim of this work was to study a group of hypertensive patients without skin diseases treated with angiotensin-converting enzyme (ACE) Inhibitors (I), to verify the presence of serum circulating anti-antibodies. The indirect immunofluorescence showed that 33 sera (52.38%) presented autoantibodies directed to an antigen of the cytoplasm of the superficial epidermal keratinocytes. Two of the 33 positive sera had antibodies to Dsg1 and/or 3 in ELISA. Immunoblot analyses were negative. All the 48 control sera were found to have no circulating antibodies using the three assays. Our results would confirm that ACEI drugs may trigger the production of circulating autoantibodies also in patients without clinical manifestations of pemphigus.

Original languageEnglish
Pages (from-to)327-332
Number of pages6
JournalArchives of Dermatological Research
Volume303
Issue number5
DOIs
Publication statusPublished - Jul 2011

Keywords

  • Angiotensin-converting enzyme inhibitors
  • Cytoplasm of the superficial cells
  • Indirect immunofluorescence
  • Induced pemphigus

ASJC Scopus subject areas

  • Dermatology

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