ACE, PAI-1, decorin and Werner helicase genes are not associated with the development of renal disease in European patients with Type 1 diabetes

S. De Cosmo, M. Margaglione, V. Tassi, M. Garrubba, S. Thomas, C. Olivetti, G. P. Piras, R. Trevisan, M. Vedovato, P. Cavallo Perin, S. Bacci, D. Colaizzo, C. Cisternino, L. Zucaro, G. Di Minno, V. Trischitta, G. C. Viberti

Research output: Contribution to journalArticle

Abstract

Background. Genetic factors are involved in the development of diabetic nephropathy in Type 1 diabetes. We have examined the association of four candidate genes, angiotensin converting enzyme (ACE): insertion/deletion (I/D) polymorphism, plasminogen activator inhibitor-1 (PAI-1): 4G/5G polymorphism, decorin: 179/183/185 polymorphism and Werner syndrome helicase: C/R polymorphism, with the presence of diabetic nephropathy in Type 1 diabetic patients. Methods. 175 Type 1 diabetic patients with albuminuria (59 with microalbuminuria and 116 with macroalbuminuria) were compared with 136 Type 12 diabetic patients with normoalbuminuria and duration of disease longer than 15 years (mean ± SD: 25 ± 8 years) 200 non-diabetic subjects were also studied as background population. Results. We found no association in the polymorphism of the four genes examined between patients with and without diabetic nephropathy and the control subjects. Conclusions. The genes studied are unlikely to be involved in the susceptibility to nephropathy in Type 1 diabetic patients.

Original languageEnglish
Pages (from-to)247-253
Number of pages7
JournalDiabetes/Metabolism Research and Reviews
Volume15
Issue number4
DOIs
Publication statusPublished - Jul 1999

    Fingerprint

Keywords

  • Albuminuria
  • Diabetic nephropathy
  • Gene polymorphism
  • Type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

De Cosmo, S., Margaglione, M., Tassi, V., Garrubba, M., Thomas, S., Olivetti, C., Piras, G. P., Trevisan, R., Vedovato, M., Cavallo Perin, P., Bacci, S., Colaizzo, D., Cisternino, C., Zucaro, L., Di Minno, G., Trischitta, V., & Viberti, G. C. (1999). ACE, PAI-1, decorin and Werner helicase genes are not associated with the development of renal disease in European patients with Type 1 diabetes. Diabetes/Metabolism Research and Reviews, 15(4), 247-253. https://doi.org/10.1002/(SICI)1520-7560(199907/08)15:4<247::AID-DMRR41>3.0.CO;2-P