Acebutolol-induced decrease of mononuclear leukocyte β-adrenoceptors in hypertension

A. Basso, L. Piantanelli, G. Cognini, S. Giunta, A. Andreoni, E. Paciaroni

Research output: Contribution to journalArticle

Abstract

The regulatory action exerted on receptors by acebutolol, a cardioselective β-blocker containing intrinsic sympathomimetic activity, has been investigated. β-Adrenoceptor affinity and density of human mononuclear leukocytes were assayed in hypertensive patients before and after treatment with 400 mg/day acebutolol. While receptor affinity showed no changes between pre- and post-treatment values, a statistically significant decrease has been demonstrated in receptor density following treatment. Blood pressure and heart rate were also measured in order to test the efficacy of the administered drug. All these parameters showed a fall in the post-treatment values. It is concluded that the partial agonist acebutolol. in spite of the fact that it acts clinically as a β-blocker. has the regulatory mechanism characteristic of agonists.

Original languageEnglish
Pages (from-to)278-283
Number of pages6
JournalPharmacology
Volume31
Issue number5
DOIs
Publication statusPublished - 1985

Keywords

  • Acebutolol
  • Hypertension
  • Intrinsic sympathomimetic activity
  • Mononuclear leukocytes
  • β-Adrenoceptor regulation

ASJC Scopus subject areas

  • Pharmacology

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    Basso, A., Piantanelli, L., Cognini, G., Giunta, S., Andreoni, A., & Paciaroni, E. (1985). Acebutolol-induced decrease of mononuclear leukocyte β-adrenoceptors in hypertension. Pharmacology, 31(5), 278-283. https://doi.org/10.1159/000138132