Acetohydroxamate in struvite stones: in vivo study.

A. Aroldi, G. Graziani, C. Castelnovo, G. Colussi, M. Surian, A. Mandressi, E. Mascheroni, I. Pazardjiklian, A. Pagano, C. Ponticelli

Research output: Contribution to journalArticlepeer-review


This report describes the results obtained with a combination of acetohydroxamic acid (AHA) and antibacterial agents in 13 patients with recurrent struvite stones complicated by refractory infections with urease-producing bacteria. Intravenous antibiotic pulses plus oral AHA achieved urine sterilisation in all. Then oral chemotherapy plus AHA was given for a mean period of 10.8 +/- 5.4 months. In four patients, the urine remained sterile, but in all the patients urinary pH remained below 6.4 and urinary NH4+ below 40 mg/dl. Despite the persistence of urea-splitting bacteria, the radiographic data showed an arrest of stone growth during the first year of treatment.

Original languageEnglish
Pages (from-to)469-472
Number of pages4
JournalProceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Medicine(all)


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