Acetyl-L-carnitine in Alzheimer disease: A short-term study on CSF neurotransmitters and neuropeptides

G. Bruno, S. Scaccianoce, M. Bonamini, F. R. Patacchioli, F. Cesarino, P. Grassini, E. Sorrentino, L. Angelucci, G. L. Lenzi

Research output: Contribution to journalArticle

Abstract

Acetyl-L-carnitine (ALCAR) is a drug currently under investigation for Alzheimer disease (AD) therapy. ALCAR seems to exert a number of central nervous system (CNS)-related effects, even though a clear pharmacological action that could explain clinical results in AD has not been identified yet. The aim of this study was to determine cerebrospinal fluid (CSF) and plasma biological correlates of ALCAR effects in AD after a short-term, high-dose, intravenous, open treatment. Results show that ALCAR CSF levels achieved under treatment were significantly higher than the ones at baseline, reflecting a good penetration through the blood-brain barrier and thus a direct CNS challenge. ALCAR treatment produced no apparent change on CSF classic neurotransmitters and their metabolite levels (homovanillic acid, 5-hydroxyindolencetic acid, MHPG, dopamine, choline). Among CSF peptides, while corticotropin-releasing hormone and adrenocorticotropic hormone remained unchanged, β-endorphins significantly decreased after treatment; plasma cortisol levels matched this reduction. Since both CSF β-endorphins and plasma cortisol decreased, one possible explanation is that ALCAR reduced the AD-dependent hypothalamic-pituitary-adrenocortical (HPA) axis hyperactivity. At present, no clear explanation can be proposed for the specific mechanism of this action.

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalAlzheimer Disease and Associated Disorders
Volume9
Issue number3
Publication statusPublished - 1995

Keywords

  • β-Endorphins
  • Acetyl-L-carnitine
  • Cerebrospinal fluid neurotransmitters

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Neuroscience(all)

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    Bruno, G., Scaccianoce, S., Bonamini, M., Patacchioli, F. R., Cesarino, F., Grassini, P., Sorrentino, E., Angelucci, L., & Lenzi, G. L. (1995). Acetyl-L-carnitine in Alzheimer disease: A short-term study on CSF neurotransmitters and neuropeptides. Alzheimer Disease and Associated Disorders, 9(3), 128-131.