Acetylcholine-mediated modulation of striatal function

Paolo Calabresi, Diego Centonze, Paolo Gubellini, Antonio Pisani, Giorgio Bernardi

Research output: Contribution to journalArticle

Abstract

Striatal spiny neurones serve as a major anatomical locus for the relay of cortical information flow through the basal ganglia. these projection neurones also represent the main synaptic target of cholinergic interneurones, whose physiological role in striatal activity still remains largely enigmatic. The striatal cholinergic system has been implicated in the pathophysiology of movement disorders such as Parkinson's disease, but the cellular mechanisms underlying cholinergic-neurone function are still unknown. On the basis of in vitro electrophysiological evidence, obtained from a rat corticostriatal-slice preparation, we propose that endogenous ACh exerts a complex modulation of striatal synaptic transmission, which produces both short-term and long-term effects. ACh-mediated mechanisms might be of crucial importance in processing the cortical inputs to the striatum. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)120-126
Number of pages7
JournalTrends in Neurosciences
Volume23
Issue number3
DOIs
Publication statusPublished - Mar 1 2000

Fingerprint

Corpus Striatum
Acetylcholine
Cholinergic Agents
Neurons
Cholinergic Neurons
Movement Disorders
Interneurons
Basal Ganglia
Synaptic Transmission
Parkinson Disease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Acetylcholine-mediated modulation of striatal function. / Calabresi, Paolo; Centonze, Diego; Gubellini, Paolo; Pisani, Antonio; Bernardi, Giorgio.

In: Trends in Neurosciences, Vol. 23, No. 3, 01.03.2000, p. 120-126.

Research output: Contribution to journalArticle

Calabresi, Paolo ; Centonze, Diego ; Gubellini, Paolo ; Pisani, Antonio ; Bernardi, Giorgio. / Acetylcholine-mediated modulation of striatal function. In: Trends in Neurosciences. 2000 ; Vol. 23, No. 3. pp. 120-126.
@article{1d1af5323871408ea340f9107e208ea5,
title = "Acetylcholine-mediated modulation of striatal function",
abstract = "Striatal spiny neurones serve as a major anatomical locus for the relay of cortical information flow through the basal ganglia. these projection neurones also represent the main synaptic target of cholinergic interneurones, whose physiological role in striatal activity still remains largely enigmatic. The striatal cholinergic system has been implicated in the pathophysiology of movement disorders such as Parkinson's disease, but the cellular mechanisms underlying cholinergic-neurone function are still unknown. On the basis of in vitro electrophysiological evidence, obtained from a rat corticostriatal-slice preparation, we propose that endogenous ACh exerts a complex modulation of striatal synaptic transmission, which produces both short-term and long-term effects. ACh-mediated mechanisms might be of crucial importance in processing the cortical inputs to the striatum. Copyright (C) 2000 Elsevier Science Ltd.",
author = "Paolo Calabresi and Diego Centonze and Paolo Gubellini and Antonio Pisani and Giorgio Bernardi",
year = "2000",
month = "3",
day = "1",
doi = "10.1016/S0166-2236(99)01501-5",
language = "English",
volume = "23",
pages = "120--126",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Acetylcholine-mediated modulation of striatal function

AU - Calabresi, Paolo

AU - Centonze, Diego

AU - Gubellini, Paolo

AU - Pisani, Antonio

AU - Bernardi, Giorgio

PY - 2000/3/1

Y1 - 2000/3/1

N2 - Striatal spiny neurones serve as a major anatomical locus for the relay of cortical information flow through the basal ganglia. these projection neurones also represent the main synaptic target of cholinergic interneurones, whose physiological role in striatal activity still remains largely enigmatic. The striatal cholinergic system has been implicated in the pathophysiology of movement disorders such as Parkinson's disease, but the cellular mechanisms underlying cholinergic-neurone function are still unknown. On the basis of in vitro electrophysiological evidence, obtained from a rat corticostriatal-slice preparation, we propose that endogenous ACh exerts a complex modulation of striatal synaptic transmission, which produces both short-term and long-term effects. ACh-mediated mechanisms might be of crucial importance in processing the cortical inputs to the striatum. Copyright (C) 2000 Elsevier Science Ltd.

AB - Striatal spiny neurones serve as a major anatomical locus for the relay of cortical information flow through the basal ganglia. these projection neurones also represent the main synaptic target of cholinergic interneurones, whose physiological role in striatal activity still remains largely enigmatic. The striatal cholinergic system has been implicated in the pathophysiology of movement disorders such as Parkinson's disease, but the cellular mechanisms underlying cholinergic-neurone function are still unknown. On the basis of in vitro electrophysiological evidence, obtained from a rat corticostriatal-slice preparation, we propose that endogenous ACh exerts a complex modulation of striatal synaptic transmission, which produces both short-term and long-term effects. ACh-mediated mechanisms might be of crucial importance in processing the cortical inputs to the striatum. Copyright (C) 2000 Elsevier Science Ltd.

UR - http://www.scopus.com/inward/record.url?scp=0034161289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034161289&partnerID=8YFLogxK

U2 - 10.1016/S0166-2236(99)01501-5

DO - 10.1016/S0166-2236(99)01501-5

M3 - Article

C2 - 10675916

AN - SCOPUS:0034161289

VL - 23

SP - 120

EP - 126

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 3

ER -