Abstract
Striatal spiny neurones serve as a major anatomical locus for the relay of cortical information flow through the basal ganglia. these projection neurones also represent the main synaptic target of cholinergic interneurones, whose physiological role in striatal activity still remains largely enigmatic. The striatal cholinergic system has been implicated in the pathophysiology of movement disorders such as Parkinson's disease, but the cellular mechanisms underlying cholinergic-neurone function are still unknown. On the basis of in vitro electrophysiological evidence, obtained from a rat corticostriatal-slice preparation, we propose that endogenous ACh exerts a complex modulation of striatal synaptic transmission, which produces both short-term and long-term effects. ACh-mediated mechanisms might be of crucial importance in processing the cortical inputs to the striatum. Copyright (C) 2000 Elsevier Science Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 120-126 |
| Number of pages | 7 |
| Journal | Trends in Neurosciences |
| Volume | 23 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1 2000 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Acetylcholine-mediated modulation of striatal function. / Calabresi, Paolo; Centonze, Diego; Gubellini, Paolo; Pisani, Antonio; Bernardi, Giorgio.
In: Trends in Neurosciences, Vol. 23, No. 3, 01.03.2000, p. 120-126.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acetylcholine-mediated modulation of striatal function
AU - Calabresi, Paolo
AU - Centonze, Diego
AU - Gubellini, Paolo
AU - Pisani, Antonio
AU - Bernardi, Giorgio
PY - 2000/3/1
Y1 - 2000/3/1
N2 - Striatal spiny neurones serve as a major anatomical locus for the relay of cortical information flow through the basal ganglia. these projection neurones also represent the main synaptic target of cholinergic interneurones, whose physiological role in striatal activity still remains largely enigmatic. The striatal cholinergic system has been implicated in the pathophysiology of movement disorders such as Parkinson's disease, but the cellular mechanisms underlying cholinergic-neurone function are still unknown. On the basis of in vitro electrophysiological evidence, obtained from a rat corticostriatal-slice preparation, we propose that endogenous ACh exerts a complex modulation of striatal synaptic transmission, which produces both short-term and long-term effects. ACh-mediated mechanisms might be of crucial importance in processing the cortical inputs to the striatum. Copyright (C) 2000 Elsevier Science Ltd.
AB - Striatal spiny neurones serve as a major anatomical locus for the relay of cortical information flow through the basal ganglia. these projection neurones also represent the main synaptic target of cholinergic interneurones, whose physiological role in striatal activity still remains largely enigmatic. The striatal cholinergic system has been implicated in the pathophysiology of movement disorders such as Parkinson's disease, but the cellular mechanisms underlying cholinergic-neurone function are still unknown. On the basis of in vitro electrophysiological evidence, obtained from a rat corticostriatal-slice preparation, we propose that endogenous ACh exerts a complex modulation of striatal synaptic transmission, which produces both short-term and long-term effects. ACh-mediated mechanisms might be of crucial importance in processing the cortical inputs to the striatum. Copyright (C) 2000 Elsevier Science Ltd.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034161289&partnerID=8YFLogxK
U2 - 10.1016/S0166-2236(99)01501-5
DO - 10.1016/S0166-2236(99)01501-5
M3 - Article
C2 - 10675916
AN - SCOPUS:0034161289
VL - 23
SP - 120
EP - 126
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 3
ER -