Acetylcholinesterase in normal and malignant human cells

C. Falugi, P. Castellani, S. Raffanti, L. Borsi, L. Zardi

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Acetylcholinesterase (AChE) activity was determined in normal and malignant human cell lines by histochemical methods. In normal human fibroblasts, no AChE activity could be demonstrated by any histochemical technique or substrate. Enzymic activity was observed in HT-1080 human fibrosarcoma cells, RD 2 human rhabdomyosarcoma cells, and SW 311 human colon carcinoma cells. Activity was localized around the nuclear envelope, in the cytoplasm and associated with the cortical region of most cells. The specificity of the reaction was shown through the use of specific cholinesterase inhibitors.

Original languageEnglish
Pages (from-to)433-446
Number of pages14
JournalBasic and Applied Histochemistry
Issue number4
Publication statusPublished - 1986


ASJC Scopus subject areas

  • Anatomy

Cite this

Falugi, C., Castellani, P., Raffanti, S., Borsi, L., & Zardi, L. (1986). Acetylcholinesterase in normal and malignant human cells. Basic and Applied Histochemistry, 30(4), 433-446.