Acetylcholinesterase inhibitors are associated with weight loss in older people with dementia: A systematic review and meta-analysis

Pinar Soysal; Ahmet Turan Isik; Brendon Stubbs; Marco Solmi; Marco Volpe; Claudio Luchini; Grazia D'Onofrio; Alberto Pilotto; Enzo Manzato; Giuseppe Sergi; Patricia Schofield; Nicola Veronese

doi:10.1136/jnnp-2016-313660

Acetylcholinesterase inhibitors are associated with weight loss in older people with dementia: A systematic review and meta-analysis

Pinar Soysal, Ahmet Turan Isik, Brendon Stubbs, Marco Solmi, Marco Volpe, Claudio Luchini, Grazia D'Onofrio, Alberto Pilotto, Enzo Manzato, Giuseppe Sergi, Patricia Schofield, Nicola Veronese

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

We conducted a systematic review and meta-analysis investigating the influence of acetylcholinesterase inhibitors (AChEIs) therapy on nutritional status and weight across observational and interventional studies. Two authors searched major electronic databases from inception until 10/14/2015 for longitudinal, open-label and randomised double-blind placebo controlled (randomised controlled trials (RCTs)) studies of AChEIs in patients with dementia reporting nutritional status outcome data. Out of 3551 initial hits, 25 studies (12 open-label trials, 9 RCTs and 4 longitudinal studies) including 10 792 patients with dementia were metaanalysed. In longitudinal studies (median follow-up 6 months), a significant cumulative incidence of weight loss between baseline and follow-up evaluation was observed (studies=2; 5%; 95% CI 1% to 34%, p

Original language	English
Journal	Journal of Neurology, Neurosurgery and Psychiatry
DOIs	https://doi.org/10.1136/jnnp-2016-313660
Publication status	Accepted/In press - Jun 3 2016

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health
Surgery
Arts and Humanities (miscellaneous)

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10.1136/jnnp-2016-313660

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Soysal, P., Isik, A. T., Stubbs, B., Solmi, M., Volpe, M., Luchini, C., D'Onofrio, G., Pilotto, A., Manzato, E., Sergi, G., Schofield, P., & Veronese, N. (Accepted/In press). Acetylcholinesterase inhibitors are associated with weight loss in older people with dementia: A systematic review and meta-analysis. Journal of Neurology, Neurosurgery and Psychiatry. https://doi.org/10.1136/jnnp-2016-313660

Acetylcholinesterase inhibitors are associated with weight loss in older people with dementia : A systematic review and meta-analysis. / Soysal, Pinar; Isik, Ahmet Turan; Stubbs, Brendon; Solmi, Marco; Volpe, Marco; Luchini, Claudio; D'Onofrio, Grazia; Pilotto, Alberto; Manzato, Enzo; Sergi, Giuseppe; Schofield, Patricia; Veronese, Nicola.

In: Journal of Neurology, Neurosurgery and Psychiatry, 03.06.2016.

Research output: Contribution to journal › Article › peer-review

Soysal, P, Isik, AT, Stubbs, B, Solmi, M, Volpe, M, Luchini, C, D'Onofrio, G, Pilotto, A, Manzato, E, Sergi, G, Schofield, P & Veronese, N 2016, 'Acetylcholinesterase inhibitors are associated with weight loss in older people with dementia: A systematic review and meta-analysis', Journal of Neurology, Neurosurgery and Psychiatry. https://doi.org/10.1136/jnnp-2016-313660

Soysal, Pinar ; Isik, Ahmet Turan ; Stubbs, Brendon ; Solmi, Marco ; Volpe, Marco ; Luchini, Claudio ; D'Onofrio, Grazia ; Pilotto, Alberto ; Manzato, Enzo ; Sergi, Giuseppe ; Schofield, Patricia ; Veronese, Nicola. / Acetylcholinesterase inhibitors are associated with weight loss in older people with dementia : A systematic review and meta-analysis. In: Journal of Neurology, Neurosurgery and Psychiatry. 2016.

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