TY - JOUR
T1 - Acetylcholinesterase inhibitors are associated with weight loss in older people with dementia
T2 - A systematic review and meta-analysis
AU - Soysal, Pinar
AU - Isik, Ahmet Turan
AU - Stubbs, Brendon
AU - Solmi, Marco
AU - Volpe, Marco
AU - Luchini, Claudio
AU - D'Onofrio, Grazia
AU - Pilotto, Alberto
AU - Manzato, Enzo
AU - Sergi, Giuseppe
AU - Schofield, Patricia
AU - Veronese, Nicola
PY - 2016/6/3
Y1 - 2016/6/3
N2 - We conducted a systematic review and meta-analysis investigating the influence of acetylcholinesterase inhibitors (AChEIs) therapy on nutritional status and weight across observational and interventional studies. Two authors searched major electronic databases from inception until 10/14/2015 for longitudinal, open-label and randomised double-blind placebo controlled (randomised controlled trials (RCTs)) studies of AChEIs in patients with dementia reporting nutritional status outcome data. Out of 3551 initial hits, 25 studies (12 open-label trials, 9 RCTs and 4 longitudinal studies) including 10 792 patients with dementia were metaanalysed. In longitudinal studies (median follow-up 6 months), a significant cumulative incidence of weight loss between baseline and follow-up evaluation was observed (studies=2; 5%; 95% CI 1% to 34%, p
AB - We conducted a systematic review and meta-analysis investigating the influence of acetylcholinesterase inhibitors (AChEIs) therapy on nutritional status and weight across observational and interventional studies. Two authors searched major electronic databases from inception until 10/14/2015 for longitudinal, open-label and randomised double-blind placebo controlled (randomised controlled trials (RCTs)) studies of AChEIs in patients with dementia reporting nutritional status outcome data. Out of 3551 initial hits, 25 studies (12 open-label trials, 9 RCTs and 4 longitudinal studies) including 10 792 patients with dementia were metaanalysed. In longitudinal studies (median follow-up 6 months), a significant cumulative incidence of weight loss between baseline and follow-up evaluation was observed (studies=2; 5%; 95% CI 1% to 34%, p
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U2 - 10.1136/jnnp-2016-313660
DO - 10.1136/jnnp-2016-313660
M3 - Article
AN - SCOPUS:84973294726
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
SN - 0022-3050
ER -