Acetylcholinesterase inhibitors are associated with weight loss in older people with dementia: A systematic review and meta-analysis

Pinar Soysal, Ahmet Turan Isik, Brendon Stubbs, Marco Solmi, Marco Volpe, Claudio Luchini, Grazia D'Onofrio, Alberto Pilotto, Enzo Manzato, Giuseppe Sergi, Patricia Schofield, Nicola Veronese

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted a systematic review and meta-analysis investigating the influence of acetylcholinesterase inhibitors (AChEIs) therapy on nutritional status and weight across observational and interventional studies. Two authors searched major electronic databases from inception until 10/14/2015 for longitudinal, open-label and randomised double-blind placebo controlled (randomised controlled trials (RCTs)) studies of AChEIs in patients with dementia reporting nutritional status outcome data. Out of 3551 initial hits, 25 studies (12 open-label trials, 9 RCTs and 4 longitudinal studies) including 10 792 patients with dementia were metaanalysed. In longitudinal studies (median follow-up 6 months), a significant cumulative incidence of weight loss between baseline and follow-up evaluation was observed (studies=2; 5%; 95% CI 1% to 34%, p

Original languageEnglish
JournalJournal of Neurology, Neurosurgery and Psychiatry
DOIs
Publication statusAccepted/In press - Jun 3 2016

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery
  • Arts and Humanities (miscellaneous)

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