Acetylcysteine and contrast agent-associated nephrotoxicity

Carlo Briguori, Fiore Manganelli, Pierfranco Scarpato, Pietro Paolo Elia, Bruno Golia, Guido Riviezzo, Stefano Lepore, Mariateresa Librera, Bruno Villari, Antonio Colombo, Bruno Ricciardelli

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Prophylactic acetylcysteine along with hydration seems to be better than hydration alone in preventing the reduction in renal function induced by a contrast dye. BACKGROUND: Contrast media can lead to acute renal failure that may occasionally require hemodialysis. METHODS: One hundred eighty-three consecutive patients with impairment of renal function, undergoing coronary and/or peripheral angiography and/or angioplasty, were randomly assigned to receive 0.45% saline intravenously and acetylcysteine (600 mg orally twice daily; group A, n = 92) or 0.45% saline intravenously alone (group B, n = 91) before and after nonionic, low-osmolality contrast dye administration. RESULTS: The baseline serum creatinine concentrations were similar (1.5 ± 0.4 mg/dl in group A vs. 1.5 ± 0.4 mg/dl in group B; p = 0.37). An increase of ≥25% in the baseline creatinine level 48 h after the procedure occurred in 6 (6.5%) of 92 patients in group A and in 10 (11%) of 91 patients in group B (p = 0.22). In the subgroup with a low (

Original languageEnglish
Pages (from-to)298-303
Number of pages6
JournalJournal of the American College of Cardiology
Volume40
Issue number2
DOIs
Publication statusPublished - Jul 17 2002

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Acetylcysteine
Contrast Media
Creatinine
Coloring Agents
Kidney
Angioplasty
Acute Kidney Injury
Osmolar Concentration
Renal Dialysis
Angiography
Serum

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Briguori, C., Manganelli, F., Scarpato, P., Elia, P. P., Golia, B., Riviezzo, G., ... Ricciardelli, B. (2002). Acetylcysteine and contrast agent-associated nephrotoxicity. Journal of the American College of Cardiology, 40(2), 298-303. https://doi.org/10.1016/S0735-1097(02)01958-7

Acetylcysteine and contrast agent-associated nephrotoxicity. / Briguori, Carlo; Manganelli, Fiore; Scarpato, Pierfranco; Elia, Pietro Paolo; Golia, Bruno; Riviezzo, Guido; Lepore, Stefano; Librera, Mariateresa; Villari, Bruno; Colombo, Antonio; Ricciardelli, Bruno.

In: Journal of the American College of Cardiology, Vol. 40, No. 2, 17.07.2002, p. 298-303.

Research output: Contribution to journalArticle

Briguori, C, Manganelli, F, Scarpato, P, Elia, PP, Golia, B, Riviezzo, G, Lepore, S, Librera, M, Villari, B, Colombo, A & Ricciardelli, B 2002, 'Acetylcysteine and contrast agent-associated nephrotoxicity', Journal of the American College of Cardiology, vol. 40, no. 2, pp. 298-303. https://doi.org/10.1016/S0735-1097(02)01958-7
Briguori C, Manganelli F, Scarpato P, Elia PP, Golia B, Riviezzo G et al. Acetylcysteine and contrast agent-associated nephrotoxicity. Journal of the American College of Cardiology. 2002 Jul 17;40(2):298-303. https://doi.org/10.1016/S0735-1097(02)01958-7
Briguori, Carlo ; Manganelli, Fiore ; Scarpato, Pierfranco ; Elia, Pietro Paolo ; Golia, Bruno ; Riviezzo, Guido ; Lepore, Stefano ; Librera, Mariateresa ; Villari, Bruno ; Colombo, Antonio ; Ricciardelli, Bruno. / Acetylcysteine and contrast agent-associated nephrotoxicity. In: Journal of the American College of Cardiology. 2002 ; Vol. 40, No. 2. pp. 298-303.
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AU - Riviezzo, Guido

AU - Lepore, Stefano

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