Abstract
This study examined the hypothesis that impaired oesophageal peristalsis was associated with delayed oesophageal clearance of acid in patients with progressive systemic sclerosis (PSS), some of whom are thought to have impaired oesophageal sensitivity to acid. Sixteen patients with PSS had: (a) oesophageal manometry and endoscopy; (b) acid perfusion of the oesophagus with simultaneous measurement of intraoesophageal pH during perfusion and for the next 10 minutes; (c) 22 hour monitoring of intraoesophageal pH; and (d) an evaluation of reflux symptoms during and after perfusion and during overnight pH monitoring. By oesophageal manometry, eight patients had normal peristalsis and eight patients had impaired peristalsis. Oesophageal endoscopy was unremarkable in patients with normal peristalsis, whereas all patients with impaired peristalsis had oesophagitis. The time needed to clear the oesophagus of perfused acid was shorter (p
| Original language | English |
|---|---|
| Pages (from-to) | 1487-1491 |
| Number of pages | 5 |
| Journal | Gut |
| Volume | 34 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1993 |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Gastroenterology
Cite this
Acid clearance and oesophageal sensitivity in patients with progressive systemic sclerosis. / Basilisco, G.; Barbera, R.; Molgora, M.; Vanoli, M.; Bianchi, P.
In: Gut, Vol. 34, No. 11, 1993, p. 1487-1491.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acid clearance and oesophageal sensitivity in patients with progressive systemic sclerosis
AU - Basilisco, G.
AU - Barbera, R.
AU - Molgora, M.
AU - Vanoli, M.
AU - Bianchi, P.
PY - 1993
Y1 - 1993
N2 - This study examined the hypothesis that impaired oesophageal peristalsis was associated with delayed oesophageal clearance of acid in patients with progressive systemic sclerosis (PSS), some of whom are thought to have impaired oesophageal sensitivity to acid. Sixteen patients with PSS had: (a) oesophageal manometry and endoscopy; (b) acid perfusion of the oesophagus with simultaneous measurement of intraoesophageal pH during perfusion and for the next 10 minutes; (c) 22 hour monitoring of intraoesophageal pH; and (d) an evaluation of reflux symptoms during and after perfusion and during overnight pH monitoring. By oesophageal manometry, eight patients had normal peristalsis and eight patients had impaired peristalsis. Oesophageal endoscopy was unremarkable in patients with normal peristalsis, whereas all patients with impaired peristalsis had oesophagitis. The time needed to clear the oesophagus of perfused acid was shorter (p
AB - This study examined the hypothesis that impaired oesophageal peristalsis was associated with delayed oesophageal clearance of acid in patients with progressive systemic sclerosis (PSS), some of whom are thought to have impaired oesophageal sensitivity to acid. Sixteen patients with PSS had: (a) oesophageal manometry and endoscopy; (b) acid perfusion of the oesophagus with simultaneous measurement of intraoesophageal pH during perfusion and for the next 10 minutes; (c) 22 hour monitoring of intraoesophageal pH; and (d) an evaluation of reflux symptoms during and after perfusion and during overnight pH monitoring. By oesophageal manometry, eight patients had normal peristalsis and eight patients had impaired peristalsis. Oesophageal endoscopy was unremarkable in patients with normal peristalsis, whereas all patients with impaired peristalsis had oesophagitis. The time needed to clear the oesophagus of perfused acid was shorter (p
UR - http://www.scopus.com/inward/record.url?scp=0027340685&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027340685&partnerID=8YFLogxK
U2 - 10.1136/gut.34.11.1487
DO - 10.1136/gut.34.11.1487
M3 - Article
C2 - 8244129
AN - SCOPUS:0027340685
VL - 34
SP - 1487
EP - 1491
JO - Gut
JF - Gut
SN - 0017-5749
IS - 11
ER -