Acid clearance and oesophageal sensitivity in patients with progressive systemic sclerosis

G. Basilisco, R. Barbera, M. Molgora, M. Vanoli, P. Bianchi

Research output: Contribution to journalArticle

Abstract

This study examined the hypothesis that impaired oesophageal peristalsis was associated with delayed oesophageal clearance of acid in patients with progressive systemic sclerosis (PSS), some of whom are thought to have impaired oesophageal sensitivity to acid. Sixteen patients with PSS had: (a) oesophageal manometry and endoscopy; (b) acid perfusion of the oesophagus with simultaneous measurement of intraoesophageal pH during perfusion and for the next 10 minutes; (c) 22 hour monitoring of intraoesophageal pH; and (d) an evaluation of reflux symptoms during and after perfusion and during overnight pH monitoring. By oesophageal manometry, eight patients had normal peristalsis and eight patients had impaired peristalsis. Oesophageal endoscopy was unremarkable in patients with normal peristalsis, whereas all patients with impaired peristalsis had oesophagitis. The time needed to clear the oesophagus of perfused acid was shorter (p

Original languageEnglish
Pages (from-to)1487-1491
Number of pages5
JournalGut
Volume34
Issue number11
DOIs
Publication statusPublished - 1993

Fingerprint

Diffuse Scleroderma
Peristalsis
Acids
Perfusion
Manometry
Esophagus
Endoscopy
Symptom Assessment
Esophagitis

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Gastroenterology

Cite this

Acid clearance and oesophageal sensitivity in patients with progressive systemic sclerosis. / Basilisco, G.; Barbera, R.; Molgora, M.; Vanoli, M.; Bianchi, P.

In: Gut, Vol. 34, No. 11, 1993, p. 1487-1491.

Research output: Contribution to journalArticle

Basilisco, G. ; Barbera, R. ; Molgora, M. ; Vanoli, M. ; Bianchi, P. / Acid clearance and oesophageal sensitivity in patients with progressive systemic sclerosis. In: Gut. 1993 ; Vol. 34, No. 11. pp. 1487-1491.
@article{b208cd24850e41c296b92f7d83302a4d,
title = "Acid clearance and oesophageal sensitivity in patients with progressive systemic sclerosis",
abstract = "This study examined the hypothesis that impaired oesophageal peristalsis was associated with delayed oesophageal clearance of acid in patients with progressive systemic sclerosis (PSS), some of whom are thought to have impaired oesophageal sensitivity to acid. Sixteen patients with PSS had: (a) oesophageal manometry and endoscopy; (b) acid perfusion of the oesophagus with simultaneous measurement of intraoesophageal pH during perfusion and for the next 10 minutes; (c) 22 hour monitoring of intraoesophageal pH; and (d) an evaluation of reflux symptoms during and after perfusion and during overnight pH monitoring. By oesophageal manometry, eight patients had normal peristalsis and eight patients had impaired peristalsis. Oesophageal endoscopy was unremarkable in patients with normal peristalsis, whereas all patients with impaired peristalsis had oesophagitis. The time needed to clear the oesophagus of perfused acid was shorter (p",
author = "G. Basilisco and R. Barbera and M. Molgora and M. Vanoli and P. Bianchi",
year = "1993",
doi = "10.1136/gut.34.11.1487",
language = "English",
volume = "34",
pages = "1487--1491",
journal = "Gut",
issn = "0017-5749",
publisher = "BMJ Publishing Group",
number = "11",

}

TY - JOUR

T1 - Acid clearance and oesophageal sensitivity in patients with progressive systemic sclerosis

AU - Basilisco, G.

AU - Barbera, R.

AU - Molgora, M.

AU - Vanoli, M.

AU - Bianchi, P.

PY - 1993

Y1 - 1993

N2 - This study examined the hypothesis that impaired oesophageal peristalsis was associated with delayed oesophageal clearance of acid in patients with progressive systemic sclerosis (PSS), some of whom are thought to have impaired oesophageal sensitivity to acid. Sixteen patients with PSS had: (a) oesophageal manometry and endoscopy; (b) acid perfusion of the oesophagus with simultaneous measurement of intraoesophageal pH during perfusion and for the next 10 minutes; (c) 22 hour monitoring of intraoesophageal pH; and (d) an evaluation of reflux symptoms during and after perfusion and during overnight pH monitoring. By oesophageal manometry, eight patients had normal peristalsis and eight patients had impaired peristalsis. Oesophageal endoscopy was unremarkable in patients with normal peristalsis, whereas all patients with impaired peristalsis had oesophagitis. The time needed to clear the oesophagus of perfused acid was shorter (p

AB - This study examined the hypothesis that impaired oesophageal peristalsis was associated with delayed oesophageal clearance of acid in patients with progressive systemic sclerosis (PSS), some of whom are thought to have impaired oesophageal sensitivity to acid. Sixteen patients with PSS had: (a) oesophageal manometry and endoscopy; (b) acid perfusion of the oesophagus with simultaneous measurement of intraoesophageal pH during perfusion and for the next 10 minutes; (c) 22 hour monitoring of intraoesophageal pH; and (d) an evaluation of reflux symptoms during and after perfusion and during overnight pH monitoring. By oesophageal manometry, eight patients had normal peristalsis and eight patients had impaired peristalsis. Oesophageal endoscopy was unremarkable in patients with normal peristalsis, whereas all patients with impaired peristalsis had oesophagitis. The time needed to clear the oesophagus of perfused acid was shorter (p

UR - http://www.scopus.com/inward/record.url?scp=0027340685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027340685&partnerID=8YFLogxK

U2 - 10.1136/gut.34.11.1487

DO - 10.1136/gut.34.11.1487

M3 - Article

C2 - 8244129

AN - SCOPUS:0027340685

VL - 34

SP - 1487

EP - 1491

JO - Gut

JF - Gut

SN - 0017-5749

IS - 11

ER -