TY - JOUR
T1 - Acid Gastroesophageal Reflux Disease and Apparent Life-Threatening Events
T2 - Simultaneous pH-metry and Cardiorespiratory Monitoring
AU - Macchini, Francesco
AU - Morandi, Anna
AU - Cognizzoli, Paola
AU - Farris, Giorgio
AU - Gentilino, Valerio
AU - Zanini, Andrea
AU - Leva, Ernesto
PY - 2017
Y1 - 2017
N2 - Aim: To investigate the prevalence and the characteristics of gastroesophageal reflux disease (GERD) in infants with apparent life threatening events (ALTE). Materials and methods: Infants with at least one episode of ALTE in absence of predisposing factors were included. All infants underwent a cardiorespiratory recording with simultaneous 24-hour pH-monitoring. Patients were divided into 3 groups according to the severity of GERD: A. Reflux Index (RI) 7%. Monthly evaluations were performed and the anti-reflux therapy was maintained till normalization of monitoring and clinic. Results: 41 infants were enrolled. GERD was found in 80% of patients (moderate in 54%, severe in 27%). A normalization of the cardiorespiratory tracks was recorded on average after 1 month for group A, 7 months for the group B and 9.5 months for group C. A significant difference was registered between group A and both group B and C (P <0.0001), as well as between the group B and C (P <0.05). Conclusion: GERD influences significantly the time of normalization of the cardiorespiratory monitoring in infants with ALTE. GERD diagnosis and treatment are mandatory in these patients.
AB - Aim: To investigate the prevalence and the characteristics of gastroesophageal reflux disease (GERD) in infants with apparent life threatening events (ALTE). Materials and methods: Infants with at least one episode of ALTE in absence of predisposing factors were included. All infants underwent a cardiorespiratory recording with simultaneous 24-hour pH-monitoring. Patients were divided into 3 groups according to the severity of GERD: A. Reflux Index (RI) 7%. Monthly evaluations were performed and the anti-reflux therapy was maintained till normalization of monitoring and clinic. Results: 41 infants were enrolled. GERD was found in 80% of patients (moderate in 54%, severe in 27%). A normalization of the cardiorespiratory tracks was recorded on average after 1 month for group A, 7 months for the group B and 9.5 months for group C. A significant difference was registered between group A and both group B and C (P <0.0001), as well as between the group B and C (P <0.05). Conclusion: GERD influences significantly the time of normalization of the cardiorespiratory monitoring in infants with ALTE. GERD diagnosis and treatment are mandatory in these patients.
KW - Apparent life threatening events
KW - Gastro-esophageal reflux disease
KW - PH-metry
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U2 - 10.1016/j.pedneo.2015.12.005
DO - 10.1016/j.pedneo.2015.12.005
M3 - Article
AN - SCOPUS:84973869971
VL - 58
SP - 43
EP - 47
JO - Pediatrics and Neonatology
JF - Pediatrics and Neonatology
SN - 1875-9572
IS - 1
ER -