Acidemia in severe acute cardiogenic pulmonary edema treated with noninvasive pressure support ventilation: A single-center experience

Chiara Lazzeri, Gian F. Gensini, Claudio Picariello, Paola Attanà, Alessio Mattesini, Marco Chiostri, Serafina Valente

Research output: Contribution to journalArticlepeer-review

Abstract

In clinical practice, acidotic patients with acute cardiogenic pulmonary edema (ACPE) are commonly considered more severe in comparison with nonacidotic patients, and data on the outcome of these patients treated with noninvasive pressure support ventilation (NIV) are lacking. The present investigation was aimed at assessing whether acidosis on admission (pH2 values significantly changed throughout the 2-h NIV treatment (P=0.019) in both groups (P=0001). In acidotic patients, pCO2 significantly decreased (51.9±15.3→47.0±12.8→44.8±12.7), whereas they increased in the nonacidotic subgroup (36.8±6.5→36.9±7.2→37.6±6.4). No difference was observed in intubation rate between acidotic (eight patients, 28.6%) and nonacidotic patients (12 patients, 32.4%) (P=0.738). In-ICCU mortality rate did not differ between (13 patients, 35.1%) and nonacidotic patients (nine patients, 32.1%) (P=0.801). Our data strongly suggest that in patients with severe ACPE treated with NIV, the presence of acidosis is not associated with adverse outcomes (early mortality and intubation rates) in these patients.

Original languageEnglish
Pages (from-to)610-615
Number of pages6
JournalJournal of Cardiovascular Medicine
Volume16
Issue number9
DOIs
Publication statusPublished - Aug 1 2015

Keywords

  • Acidemia
  • Acute cardiogenic pulmonary edema
  • Intubation rate
  • Noninvasive ventilation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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