L'acidosi è associata ad un accumulo intracellulare di Ca2+. Ruolo nella modulazione della contrattilità miocardica.

Translated title of the contribution: Acidosis is associated with an intracellular accumulation of Ca2+. Its role in the modulation of myocardial contractility

G. Gambassi, M. C. Capogrossi

Research output: Contribution to journalArticle

Abstract

Myocardial acidosis, as during ischemia, profoundly modifies excitation-contraction mechanisms. The decreased myofilament sensitivity to Ca2+ reduces contractility regardless of an intracellular accumulation of Ca2+. To determine the source for this increase in Ca2+ we evaluated the effect of acidosis on diastolic [Ca2+] and mitochondrial [Ca2+]. We used single cardiac cells loaded with the fluorescent probes, indo-1 for Ca2+ and SNARF-1 for pH. Acidosis increases [Ca2+] both in cytosol and mitochondria. The cytosolic accumulation depends, most likely, on an active release from mitochondria. A competition among Ca2+ and H+ ions may, instead, explains the increase in mitochondrial [Ca2+].

Original languageItalian
Pages (from-to)587-589
Number of pages3
JournalCardiologia
Volume37
Issue number8
Publication statusPublished - Aug 1992

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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