Acne and lipid pathways

Christos C. Zouboulis; Eric Jourdan; Mauro Picardo

doi:10.1007/978-3-319-09943-9_23

Acne and lipid pathways

Christos C. Zouboulis, Eric Jourdan, Mauro Picardo

Istituto S. Maria e S. Gallicano

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Hyperseborrhea has been considered as a major etiopathogenetic factor of acne. However, changes in sebaceous gland activity not only correlate with seborrhea but also with alterations in sebum fatty acid composition. Current findings indicate that sebum lipid fractions with proinflammatory properties and inflammatory tissue cascades are associated in the process of the development of acne lesions. The oxidant/antioxidant ratio of the skin surface lipids and alterations of lipid composition are the main players in the induction of acne inflammation. Nutrition may influence the development of seborrhea, the fractions of sebum lipids, and acne. Acne is an inflammatory disease probably triggered, among others, by proinflammatory sebum lipid fractions.

Original language	English
Title of host publication	Lipids and Skin Health
Publisher	Springer International Publishing
Pages	331-342
Number of pages	12
ISBN (Print)	9783319099439, 9783319099422
DOIs	https://doi.org/10.1007/978-3-319-09943-9_23
Publication status	Published - Jan 1 2015

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)
Engineering(all)
Agricultural and Biological Sciences(all)

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10.1007/978-3-319-09943-9_23

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AB - Hyperseborrhea has been considered as a major etiopathogenetic factor of acne. However, changes in sebaceous gland activity not only correlate with seborrhea but also with alterations in sebum fatty acid composition. Current findings indicate that sebum lipid fractions with proinflammatory properties and inflammatory tissue cascades are associated in the process of the development of acne lesions. The oxidant/antioxidant ratio of the skin surface lipids and alterations of lipid composition are the main players in the induction of acne inflammation. Nutrition may influence the development of seborrhea, the fractions of sebum lipids, and acne. Acne is an inflammatory disease probably triggered, among others, by proinflammatory sebum lipid fractions.

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Acne and lipid pathways

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ASJC Scopus subject areas

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