Acne and lipid pathways

Christos C. Zouboulis, Eric Jourdan, Mauro Picardo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Hyperseborrhea has been considered as a major etiopathogenetic factor of acne. However, changes in sebaceous gland activity not only correlate with seborrhea but also with alterations in sebum fatty acid composition. Current findings indicate that sebum lipid fractions with proinflammatory properties and inflammatory tissue cascades are associated in the process of the development of acne lesions. The oxidant/antioxidant ratio of the skin surface lipids and alterations of lipid composition are the main players in the induction of acne inflammation. Nutrition may influence the development of seborrhea, the fractions of sebum lipids, and acne. Acne is an inflammatory disease probably triggered, among others, by proinflammatory sebum lipid fractions.

Original languageEnglish
Title of host publicationLipids and Skin Health
PublisherSpringer International Publishing
Pages331-342
Number of pages12
ISBN (Print)9783319099439, 9783319099422
DOIs
Publication statusPublished - Jan 1 2015

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Engineering(all)
  • Agricultural and Biological Sciences(all)

Cite this

Zouboulis, C. C., Jourdan, E., & Picardo, M. (2015). Acne and lipid pathways. In Lipids and Skin Health (pp. 331-342). Springer International Publishing. https://doi.org/10.1007/978-3-319-09943-9_23