Acoustic radial force impulse as an effective tool for a prompt and reliable diagnosis of hepatocellular carcinoma - Preliminary data

L. Rizzo, G. Nunnari, M. Berretta, B. Cacopardo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

ARFI (Acoustic Radiation Force Impulse) is a novel method based on the use of shear acoustic waves remotely induced by the radiation force of a focused ultrasonic beam. Recently, ARFI has been investigated as a non-invasive method for the assessment of liver fibrosis. The reproducibility of ARFI technology was proved in determining liver fibrosis: in detail, for cirrhosis Fibroscan had its best cut-off at ≥ 11 kPa (AUROC of 0.80) whereas ARFI ≥ 2.0 m/s (AUROC of 0.89). By pair-wise comparison of AUROC, ARFI was significantly more accurate than TE for a diagnosis of significant and severe fibrosis. Due to the low amount of collagen deposition within hepatocellular carcinoma (HCC) nodules in a context of "hard" cirrhotic parenchyma, ARFI propose itself also as a novel, specific method for an early identification of primitive neoplastic nodules during the follow up of cirrhotic patients. The diagnostic accuracy can be demonstrated either versus the surrounding liver tissue or versus dysplastic or metastatic nodules. Further studies are required to confirm ARFI as a useful tool for HCC follow-up.

Original languageEnglish
Pages (from-to)1596-1598
Number of pages3
JournalEuropean Review for Medical and Pharmacological Sciences
Volume16
Issue number11
Publication statusPublished - 2012

Fingerprint

Acoustics
Hepatocellular Carcinoma
Radiation
Liver Cirrhosis
Fibrosis
Ultrasonics
Collagen
Technology
Liver

Keywords

  • Acoustic radiation force impulse
  • Cirrhotic parenchyma
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

Cite this

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AU - Nunnari, G.

AU - Berretta, M.

AU - Cacopardo, B.

PY - 2012

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AB - ARFI (Acoustic Radiation Force Impulse) is a novel method based on the use of shear acoustic waves remotely induced by the radiation force of a focused ultrasonic beam. Recently, ARFI has been investigated as a non-invasive method for the assessment of liver fibrosis. The reproducibility of ARFI technology was proved in determining liver fibrosis: in detail, for cirrhosis Fibroscan had its best cut-off at ≥ 11 kPa (AUROC of 0.80) whereas ARFI ≥ 2.0 m/s (AUROC of 0.89). By pair-wise comparison of AUROC, ARFI was significantly more accurate than TE for a diagnosis of significant and severe fibrosis. Due to the low amount of collagen deposition within hepatocellular carcinoma (HCC) nodules in a context of "hard" cirrhotic parenchyma, ARFI propose itself also as a novel, specific method for an early identification of primitive neoplastic nodules during the follow up of cirrhotic patients. The diagnostic accuracy can be demonstrated either versus the surrounding liver tissue or versus dysplastic or metastatic nodules. Further studies are required to confirm ARFI as a useful tool for HCC follow-up.

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