Acoustic radiation force impulse (ARFI) imaging con Virtual Touch Tissue Quantification nella valutazione della epatopatia associata alla fibrosi cistica nei bambini

Translated title of the contribution: Acoustic radiation force impulse (ARFI) imaging with Virtual Touch Tissue Quantification in liver disease associated with cystic fibrosis in children

L. Monti, M. Manco, C. Lo Zupone, A. Latini, M. L. D'Andrea, F. Alghisi, V. Lucidi, P. Tomà, L. Bonomo

Research output: Contribution to journalArticle


Purpose: Cystic-fibrosis-associated liver disease (CFLD) may lead to portal hypertension (PHT) and cirrhosis. Clinical signs and biochemistry of liver involvement are not discriminating. The aim of the study was to evaluate the performance of acoustic radiation force impulse (ARFI) with virtual tissue quantification in comparison with clinical signs, biochemistry and standard hepatic ultrasound (US) patterns. Materials and methods: Virtual Touch Tissue Quantification, an implementation of US ARFI with shear-wave velocity (SWV) measurements was used in 75 children with cystic fibrosis (CF) and suspected CFLD to quantify hepatic stiffness. In each patient, ten measurements of SWV were performed on the right hepatic lobe. Patients were also evaluated by standard diagnostic tools (standard US, liver- and lung function tests, oesophagogastroscopy). Results: Among CF patients, median SWV was significantly higher in patients with clinical, biochemical and US signs of hepatic involvement than in patients without US evidence of liver disease 1.08 m/s [(95% confidence interval (CI), 1.02-1.14]. Median SWV values in patients with portal hypertension, splenomegaly and oesophageal varices were 1.30 (95% CI, 1.17-1.43), 1.54 (95% CI, 1.32-1.75) and 1.63 (95% CI, 1.26-1.99), respectively. Differences were significant (p

Original languageItalian
Pages (from-to)1408-1418
Number of pages11
JournalRadiologia Medica
Issue number8
Publication statusPublished - Dec 2012


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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