Acquired control of ventral premotor cortex activity by feedback training: An exploratory real-time fMRI and TMS study

Ranganatha Sitaram, Ralf Veit, Birte Stevens, Andrea Caria, Christian Gerloff, Niels Birbaumer, Friedhelm Hummel

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Background. Despite the availability of various options for movement restoration in stroke patients, there is no effective treatment for patients who show little or no functional recovery of upper limb motor function. Objective. The present study explored the feasibility of real-time functional magnetic resonance imaging brain-computer interface (fMRI-BCI) as a new tool for rehabilitation of this patient population. Methods. Healthy adults and chronic subcortical stroke patients with residual movement were trained for 3 days to regulate the blood oxygenation level dependent (BOLD) response in the ventral premotor cortex (PMv), a secondary motor area with extensive anatomic connections with the primary motor cortex. Effect of learned modulation of the PMv was evaluated with BOLD signal changes across training sessions, transcranial magnetic stimulation (TMS), and a visuomotor task. Results. fMRI-BCI feedback training showed learning with a significantly increasing BOLD signal in the PMv over sessions. Participants' capability to learn self-regulation was found to depend linearly on intracortical facilitation and correlated negatively with intracortical inhibition measured by TMS prior to feedback training. After training, intracortical inhibition decreased significantly with the volitional increase of the BOLD response in the PMv, indicating a beneficial effect of self-regulation training on motor cortical output. Conclusion. The study provides first evidence for the therapeutic potential of fMRI-BCI in stroke rehabilitation.

Original languageEnglish
Pages (from-to)256-265
Number of pages10
JournalNeurorehabilitation and Neural Repair
Volume26
Issue number3
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Transcranial Magnetic Stimulation
Motor Cortex
Brain-Computer Interfaces
Teaching
Magnetic Resonance Imaging
Stroke
Feasibility Studies
Upper Extremity
Rehabilitation
Learning
Therapeutics
Population
Inhibition (Psychology)
Self-Control

Keywords

  • BCI
  • premotor cortex
  • real-time fMRI
  • stroke
  • TMS
  • visuomotor tracking task

ASJC Scopus subject areas

  • Clinical Neurology
  • Rehabilitation
  • Neurology

Cite this

Acquired control of ventral premotor cortex activity by feedback training : An exploratory real-time fMRI and TMS study. / Sitaram, Ranganatha; Veit, Ralf; Stevens, Birte; Caria, Andrea; Gerloff, Christian; Birbaumer, Niels; Hummel, Friedhelm.

In: Neurorehabilitation and Neural Repair, Vol. 26, No. 3, 03.2012, p. 256-265.

Research output: Contribution to journalArticle

Sitaram, Ranganatha ; Veit, Ralf ; Stevens, Birte ; Caria, Andrea ; Gerloff, Christian ; Birbaumer, Niels ; Hummel, Friedhelm. / Acquired control of ventral premotor cortex activity by feedback training : An exploratory real-time fMRI and TMS study. In: Neurorehabilitation and Neural Repair. 2012 ; Vol. 26, No. 3. pp. 256-265.
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