Acquired haemophilia A: A 2013 update

Massimo Franchini, Pier Mannuccio Mannucci

Research output: Contribution to journalArticlepeer-review


Acquired haemophilia A (AHA) is a rare but often severe bleeding disorder caused by autoantibodies against coagulation factor VIII (FVIII). AHA occurs more frequently in the elderly and in association with several conditions, such as the post-partum period, malignancies, autoimmune diseases or drug exposure; however, approximately 50% of reported cases are apparently idiopathic. Beside the elimination of the underlying disorder, the therapeutic approach to AHA should be directed toward the control of acute bleed and the eradication of FVIII autoantibody production. In this narrative review, we summarise the current knowledge on the epidemiology, diagnosis and clinical features of AHA, focusing in particular on advances in the management of this challenging bleeding disorder.

Original languageEnglish
Pages (from-to)1114-1120
Number of pages7
JournalThrombosis and Haemostasis
Issue number6
Publication statusPublished - Sep 5 2013


  • Acquired haemophilia A
  • Auto-antibodies
  • Bleeding
  • Inhibitors
  • Therapy

ASJC Scopus subject areas

  • Hematology


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