Acquired platelet dysfunction and overproduction of platelet cyclic AMP in two patients with myeloid malignancies

Research output: Contribution to journalArticle

Abstract

The pathophysiology of impaired platelet function in acquired disorders is often poorly understood. We report two unrelated patients with hematologic malignancies associated with acquired severe bleeding diathesis, and complex platelet function abnormalities, including overproduction of the physiological inhibitor cyclic-AMP (cAMP). Patient 1, with mild macrocytic anemia and thrombocytopenia (100 x 109/L), was diagnosed with chronic myelomonocytic leukemia a few months after the onset of her bleeding diathesis and our analysis of platelet function. Patient 2, with bleeding diathesis of recent onset, was studied when his myelodysplastic syndrome with excess blasts had already progressed to acute myeloid leukemia. In both patients, platelet aggregation/ATP secretion, serum thromboxane B2, intraplatelet content of ADP, ATP, serotonin, and fibrinogen were severely impaired. Baseline platelet cAMP levels were mildly elevated and markedly increased after stimulation by prostaglandin E1. In conclusion, these are the first patients with myeloid malignancies associated with acquired severe platelet dysfunction and overproduction of cAMP.

Original languageEnglish
Pages (from-to)1053-1056
JournalPlatelets
Volume30
Issue number8
DOIs
Publication statusPublished - Jan 1 2019

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Keywords

  • Blood Platelet Disorders
  • cyclic AMP
  • Myelodysplastic Syndrome (MDS)
  • Myeloid Leukemia
  • Platelet Function Tests

ASJC Scopus subject areas

  • Hematology

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