Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic leukemia

Mignon L. Loh, Simone Martinelli, Viviana Cordeddu, Melissa G. Reynolds, Shashaank Vattikuti, Connie M. Lee, Michael Wulfert, Ulrich Germing, Peter Haas, Charlotte Niemeyer, Miloslav E. Beran, Sara Strom, Michael Lübbert, Mariella Sorcini, Elihu H. Estey, Norbert Gattermann, Marco Tartaglia

Research output: Contribution to journalArticle

Abstract

Myelodysplastic syndromes (MDS) are comprised of a heterogeneous group of stem cell disorders characterized by ineffective hematopoiesis and susceptibility to transform to acute myeloid leukemia. The molecular pathways underlying disease initiation and evolution are still largely unknown. We recently demonstrated that acquired mutations in PTPN11 are a major event in JMML and occur with variable prevalence in children with other hematologic malignancies, including MDS. Here, we investigated contribution of PTPN11 mutations to adult MDS and CMML pathogenesis. Our results indicate that PTPN11 lesions might play a role in adult MDS/CMML pathogenesis but do not represent a major molecular event.

Original languageEnglish
Pages (from-to)459-462
Number of pages4
JournalLeukemia Research
Volume29
Issue number4
DOIs
Publication statusPublished - Apr 2005

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Keywords

  • CMML
  • MDS
  • PTPN11
  • RAS signaling
  • SHP-2

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Loh, M. L., Martinelli, S., Cordeddu, V., Reynolds, M. G., Vattikuti, S., Lee, C. M., Wulfert, M., Germing, U., Haas, P., Niemeyer, C., Beran, M. E., Strom, S., Lübbert, M., Sorcini, M., Estey, E. H., Gattermann, N., & Tartaglia, M. (2005). Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic leukemia. Leukemia Research, 29(4), 459-462. https://doi.org/10.1016/j.leukres.2004.10.001