Acquired self-control of insula cortex modulates emotion recognition and brain network connectivity in schizophrenia

Sergio Ruiz, Sangkyun Lee, Surjo R. Soekadar, Andrea Caria, Ralf Veit, Tilo Kircher, Niels Birbaumer, Ranganatha Sitaram

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Real-time functional magnetic resonance imaging (rtfMRI) is a novel technique that has allowed subjects to achieve self-regulation of circumscribed brain regions. Despite its anticipated therapeutic benefits, there is no report on successful application of this technique in psychiatric populations. The objectives of the present study were to train schizophrenia patients to achieve volitional control of bilateral anterior insula cortex on multiple days, and to explore the effect of learned self-regulation on face emotion recognition (an extensively studied deficit in schizophrenia) and on brain network connectivity. Nine patients with schizophrenia were trained to regulate the hemodynamic response in bilateral anterior insula with contingent rtfMRI neurofeedback, through a 2-weeks training. At the end of the training stage, patients performed a face emotion recognition task to explore behavioral effects of learned self-regulation. A learning effect in self-regulation was found for bilateral anterior insula, which persisted through the training. Following successful self-regulation, patients recognized disgust faces more accurately and happy faces less accurately. Improvements in disgust recognition were correlated with levels of self-activation of right insula. RtfMRI training led to an increase in the number of the incoming and outgoing effective connections of the anterior insula. This study shows for the first time that patients with schizophrenia can learn volitional brain regulation by rtfMRI feedback training leading to changes in the perception of emotions and modulations of the brain network connectivity. These findings open the door for further studies of rtfMRI in severely ill psychiatric populations, and possible therapeutic applications.

Original languageEnglish
Pages (from-to)200-212
Number of pages13
JournalHuman Brain Mapping
Volume34
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Schizophrenia
Emotions
Magnetic Resonance Imaging
Brain
Psychiatry
Neurofeedback
Population
Hemodynamics
Recognition (Psychology)
Self-Control
Learning
Therapeutics
Facial Recognition

Keywords

  • Face emotion recognition
  • Insula
  • Neurofeedback
  • Real-time fMRI
  • Schizophrenia
  • Self-regulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Ruiz, S., Lee, S., Soekadar, S. R., Caria, A., Veit, R., Kircher, T., ... Sitaram, R. (2013). Acquired self-control of insula cortex modulates emotion recognition and brain network connectivity in schizophrenia. Human Brain Mapping, 34(1), 200-212. https://doi.org/10.1002/hbm.21427

Acquired self-control of insula cortex modulates emotion recognition and brain network connectivity in schizophrenia. / Ruiz, Sergio; Lee, Sangkyun; Soekadar, Surjo R.; Caria, Andrea; Veit, Ralf; Kircher, Tilo; Birbaumer, Niels; Sitaram, Ranganatha.

In: Human Brain Mapping, Vol. 34, No. 1, 01.2013, p. 200-212.

Research output: Contribution to journalArticle

Ruiz, S, Lee, S, Soekadar, SR, Caria, A, Veit, R, Kircher, T, Birbaumer, N & Sitaram, R 2013, 'Acquired self-control of insula cortex modulates emotion recognition and brain network connectivity in schizophrenia', Human Brain Mapping, vol. 34, no. 1, pp. 200-212. https://doi.org/10.1002/hbm.21427
Ruiz, Sergio ; Lee, Sangkyun ; Soekadar, Surjo R. ; Caria, Andrea ; Veit, Ralf ; Kircher, Tilo ; Birbaumer, Niels ; Sitaram, Ranganatha. / Acquired self-control of insula cortex modulates emotion recognition and brain network connectivity in schizophrenia. In: Human Brain Mapping. 2013 ; Vol. 34, No. 1. pp. 200-212.
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