Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan

Arash Ghodousi; Alamdar Hussain Rizvi; Aurangzaib Quadir Baloch; Abdul Ghafoor; Faisal Masood Khanzada; Mehmood Qadir; Emanuele Borroni; Alberto Trovato; Sabira Tahseen; Daniela Maria Cirillo

doi:10.1128/AAC.00915-19

Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan

Arash Ghodousi, Alamdar Hussain Rizvi, Aurangzaib Quadir Baloch, Abdul Ghafoor, Faisal Masood Khanzada, Mehmood Qadir, Emanuele Borroni, Alberto Trovato, Sabira Tahseen, Daniela Maria Cirillo

Research output: Contribution to journal › Article › peer-review

Abstract

We report on the first six cases of acquired resistance to bedaquiline in Pakistan. Seventy sequential isolates from 30 drug-resistant-tuberculosis patients on bedaquiline-containing regimens were retrospectively tested for bedaquiline resistance by MIC testing and by the detection of mutations in relevant genes. We documented cases failing therapy that developed specific mutations in Rv0678 and had increased MICs associated with cross-resistance to clofazimine during treatment. This study underlines the relevance of surveillance programs following the introduction of new drugs.

Original language	English
Article number	e00915-19
Journal	Antimicrobial Agents and Chemotherapy
Volume	63
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00915-19
Publication status	Published - Jan 1 2019

Keywords

Antibiotic resistance
Bedaquiline
Clofazimine
Multidrug resistance
Tuberculosis
Whole-genome sequencing
XDR

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan. / Ghodousi, Arash; Rizvi, Alamdar Hussain; Baloch, Aurangzaib Quadir; Ghafoor, Abdul; Khanzada, Faisal Masood; Qadir, Mehmood; Borroni, Emanuele; Trovato, Alberto; Tahseen, Sabira; Cirillo, Daniela Maria.

In: Antimicrobial Agents and Chemotherapy, Vol. 63, No. 9, e00915-19, 01.01.2019.

Research output: Contribution to journal › Article › peer-review

Ghodousi, Arash ; Rizvi, Alamdar Hussain ; Baloch, Aurangzaib Quadir ; Ghafoor, Abdul ; Khanzada, Faisal Masood ; Qadir, Mehmood ; Borroni, Emanuele ; Trovato, Alberto ; Tahseen, Sabira ; Cirillo, Daniela Maria. / Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan. In: Antimicrobial Agents and Chemotherapy. 2019 ; Vol. 63, No. 9.

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