Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan

Arash Ghodousi, Alamdar Hussain Rizvi, Aurangzaib Quadir Baloch, Abdul Ghafoor, Faisal Masood Khanzada, Mehmood Qadir, Emanuele Borroni, Alberto Trovato, Sabira Tahseen, Daniela Maria Cirillo

Research output: Contribution to journalArticlepeer-review

Abstract

We report on the first six cases of acquired resistance to bedaquiline in Pakistan. Seventy sequential isolates from 30 drug-resistant-tuberculosis patients on bedaquiline-containing regimens were retrospectively tested for bedaquiline resistance by MIC testing and by the detection of mutations in relevant genes. We documented cases failing therapy that developed specific mutations in Rv0678 and had increased MICs associated with cross-resistance to clofazimine during treatment. This study underlines the relevance of surveillance programs following the introduction of new drugs.

Original languageEnglish
Article numbere00915-19
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number9
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Antibiotic resistance
  • Bedaquiline
  • Clofazimine
  • Multidrug resistance
  • Tuberculosis
  • Whole-genome sequencing
  • XDR

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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