Acquisition of different carbapenem resistance mechanisms by an epidemic clonal lineage of Pseudomonas aeruginosa

E. Edalucci, R. Spinelli, L. Dolzani, M. Letizia Riccio, V. Dubois, E. Angelo Tonin, G. M. Rossolini, C. Lagatolla

Research output: Contribution to journalArticlepeer-review

Abstract

Multidrug-resistant isolates of a clonal lineage of Pseudomonas aeruginosa producing the VIM-2 metallo-β-lactamase (MBL), involved in a large outbreak in an Italian hospital, were compared with MBL-negative strains that had caused outbreaks in two French hospitals. Although the isolates had different carbapenem MICs, the VIM-2-producing isolates from Italy carried identical, or very similar, allelic forms of the oprD gene, harboured a common class1 integron, belonged to the same multilocus sequence type (ST111), and showed macrorestriction profiles that were related to those of the MBL-negative French strains. These results support the concept of independent acquisition of resistance determinants by members of a widespread clonal lineage of P. aeruginosa.

Original languageEnglish
Pages (from-to)88-90
Number of pages3
JournalClinical Microbiology and Infection
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Carbapenem resistance
  • Clonal lineage
  • Metallo-β-lactamase
  • Pseudomonas aeruginosa
  • Resistance acquisition
  • VIM-2

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

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