AcrAB efflux system

Expression and contribution to fluoroquinolone resistance in Klebsiella spp.

Annarita Mazzariol, Jessica Zuliani, Giuseppe Cornaglia, Gian Maria Rossolini, Roberta Fontana

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Seven Klebsiella pneumoniae and four Klebsiella oxytoca clinical isolates with different levels of resistance to ciprofloxacin were studied. Mutations in the topoisomerase genes were found in almost all strains, but the contribution of a multidrug efflux system homologous to AcrAB in Escherichia coli was also observed. Over-expression of this efflux system was demonstrated by immunoblotting with antibodies against E. coli AcrA.

Original languageEnglish
Pages (from-to)3984-3986
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume46
Issue number12
DOIs
Publication statusPublished - Dec 1 2002

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Klebsiella
Fluoroquinolones
Klebsiella oxytoca
Escherichia coli
Klebsiella pneumoniae
Ciprofloxacin
Immunoblotting
Mutation
Antibodies
Genes

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

AcrAB efflux system : Expression and contribution to fluoroquinolone resistance in Klebsiella spp. / Mazzariol, Annarita; Zuliani, Jessica; Cornaglia, Giuseppe; Rossolini, Gian Maria; Fontana, Roberta.

In: Antimicrobial Agents and Chemotherapy, Vol. 46, No. 12, 01.12.2002, p. 3984-3986.

Research output: Contribution to journalArticle

Mazzariol, Annarita ; Zuliani, Jessica ; Cornaglia, Giuseppe ; Rossolini, Gian Maria ; Fontana, Roberta. / AcrAB efflux system : Expression and contribution to fluoroquinolone resistance in Klebsiella spp. In: Antimicrobial Agents and Chemotherapy. 2002 ; Vol. 46, No. 12. pp. 3984-3986.
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