Abstract
Seven Klebsiella pneumoniae and four Klebsiella oxytoca clinical isolates with different levels of resistance to ciprofloxacin were studied. Mutations in the topoisomerase genes were found in almost all strains, but the contribution of a multidrug efflux system homologous to AcrAB in Escherichia coli was also observed. Over-expression of this efflux system was demonstrated by immunoblotting with antibodies against E. coli AcrA.
| Original language | English |
|---|---|
| Pages (from-to) | 3984-3986 |
| Number of pages | 3 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 46 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1 2002 |
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ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
AcrAB efflux system : Expression and contribution to fluoroquinolone resistance in Klebsiella spp. / Mazzariol, Annarita; Zuliani, Jessica; Cornaglia, Giuseppe; Rossolini, Gian Maria; Fontana, Roberta.
In: Antimicrobial Agents and Chemotherapy, Vol. 46, No. 12, 01.12.2002, p. 3984-3986.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - AcrAB efflux system
T2 - Expression and contribution to fluoroquinolone resistance in Klebsiella spp.
AU - Mazzariol, Annarita
AU - Zuliani, Jessica
AU - Cornaglia, Giuseppe
AU - Rossolini, Gian Maria
AU - Fontana, Roberta
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Seven Klebsiella pneumoniae and four Klebsiella oxytoca clinical isolates with different levels of resistance to ciprofloxacin were studied. Mutations in the topoisomerase genes were found in almost all strains, but the contribution of a multidrug efflux system homologous to AcrAB in Escherichia coli was also observed. Over-expression of this efflux system was demonstrated by immunoblotting with antibodies against E. coli AcrA.
AB - Seven Klebsiella pneumoniae and four Klebsiella oxytoca clinical isolates with different levels of resistance to ciprofloxacin were studied. Mutations in the topoisomerase genes were found in almost all strains, but the contribution of a multidrug efflux system homologous to AcrAB in Escherichia coli was also observed. Over-expression of this efflux system was demonstrated by immunoblotting with antibodies against E. coli AcrA.
UR - http://www.scopus.com/inward/record.url?scp=0036895630&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036895630&partnerID=8YFLogxK
U2 - 10.1128/AAC.46.12.3984-3986.2002
DO - 10.1128/AAC.46.12.3984-3986.2002
M3 - Article
VL - 46
SP - 3984
EP - 3986
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 12
ER -