TY - JOUR
T1 - Acromegaly is associated with increased cancer risk
T2 - A survey in Italy
AU - Terzolo, Massimo
AU - Reimondo, Giuseppe
AU - Berchialla, Paola
AU - Ferrante, Emanuele
AU - Malchiodi, Elena
AU - De Marinis, Laura
AU - Pivonello, Rosario
AU - Grottoli, Silvia
AU - Losa, Marco
AU - Cannavo, Salvatore
AU - Ferone, Diego
AU - Montini, Marcella
AU - Bondanelli, Marta
AU - De Menis, Ernesto
AU - Martini, Chiara
AU - Puxeddu, Efisio
AU - Velardo, Antonino
AU - Peri, Alessandro
AU - Faustini-Fustini, Marco
AU - Tita, Patrizia
AU - Pigliaru, Francesca
AU - Peraga, Giulia
AU - Borretta, Giorgio
AU - Scaroni, Carla
AU - Bazzoni, Nicoletta
AU - Bianchi, Antonio
AU - Berton, Alessandro
AU - Serban, Andreea Liliana
AU - Baldelli, Roberto
AU - Fatti, Letizia Maria
AU - Colao, Annamaria
AU - Arosio, Maura
AU - Lombardi, G.
AU - Trimarchi, F.
AU - Degli Uberti, E. C.
AU - Ambrosio, M. R.
AU - Pagani, G.
AU - Attanasio, R.
AU - Kara, E.
AU - Mantero, F.
AU - Ceccato, F.
AU - Mortini, P.
AU - Razzore, P.
AU - Angeletti, G.
AU - Della Torre, D.
AU - Mariotti, S.
AU - Appetecchia, M.
AU - Nazzari, E.
AU - Cavagnini, F.
AU - Persani, L.
AU - Italian Study Group of Acromegaly
PY - 2017/9/1
Y1 - 2017/9/1
N2 - It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in acromegaly on a large series of acromegalic patients managed in the somatostatin analogs era. It was evaluated the incidence of cancer in an Italian nationwide multicenter cohort study of 1512 acromegalic patients, 624 men and 888 women, mean age at diagnosis 45 ± 13 years, followed up for a mean of 10 years (12573 person-years) in respect to the general Italian population. Cancer was diagnosed in 124 patients, 72 women and 52 men. The SIRs for all cancers was significantly increased compared to the general Italian population (expected: 88, SIR 1.41; 95% CI, 1.18-1.68, P < 0.001). In the whole series, we found a significantly increased incidence of colorectal cancer (SIR 1.67; 95% CI, 1.07-2.58, P = 0.022), kidney cancer (SIR 2.87; 95% CI, 1.55-5.34, P < 0.001) and thyroid cancer (SIR 3.99; 95% CI, 2.32-6.87, P < 0.001). The exclusion of 11 cancers occurring before diagnosis of acromegaly (all in women) did not change remarkably the study outcome. In multivariate analysis, the factors significantly associated with an increased risk of malignancy were age and family history of cancer, with a non-significant trend for the estimated duration of acromegaly before diagnosis. In conclusion, we found evidence that acromegaly in Italy is associated with a moderate increase in cancer risk.
AB - It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in acromegaly on a large series of acromegalic patients managed in the somatostatin analogs era. It was evaluated the incidence of cancer in an Italian nationwide multicenter cohort study of 1512 acromegalic patients, 624 men and 888 women, mean age at diagnosis 45 ± 13 years, followed up for a mean of 10 years (12573 person-years) in respect to the general Italian population. Cancer was diagnosed in 124 patients, 72 women and 52 men. The SIRs for all cancers was significantly increased compared to the general Italian population (expected: 88, SIR 1.41; 95% CI, 1.18-1.68, P < 0.001). In the whole series, we found a significantly increased incidence of colorectal cancer (SIR 1.67; 95% CI, 1.07-2.58, P = 0.022), kidney cancer (SIR 2.87; 95% CI, 1.55-5.34, P < 0.001) and thyroid cancer (SIR 3.99; 95% CI, 2.32-6.87, P < 0.001). The exclusion of 11 cancers occurring before diagnosis of acromegaly (all in women) did not change remarkably the study outcome. In multivariate analysis, the factors significantly associated with an increased risk of malignancy were age and family history of cancer, with a non-significant trend for the estimated duration of acromegaly before diagnosis. In conclusion, we found evidence that acromegaly in Italy is associated with a moderate increase in cancer risk.
KW - Acromegaly cancer
KW - Gh IGF1
UR - http://www.scopus.com/inward/record.url?scp=85041211091&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041211091&partnerID=8YFLogxK
U2 - 10.1530/ERC-16-0553
DO - 10.1530/ERC-16-0553
M3 - Review article
AN - SCOPUS:85041211091
VL - 24
SP - 495
EP - 504
JO - Endocrine-Related Cancer
JF - Endocrine-Related Cancer
SN - 1351-0088
IS - 9
ER -