Acromegaly is associated with increased cancer risk: a survey in Italy

M Terzolo, G Reimondo, P Berchialla, E Ferrante, E Malchiodi, L De Marinis, R Pivonello, S Grottoli, M Losa, S Cannavo, D Ferone, M Montini, M Bondanelli, E De Menis, C Martini, E Puxeddu, A Velardo, A Peri, M Faustini-Fustini, P TitaF Pigliaru, G Peraga, G Borretta, C Scaroni, N Bazzoni, A Bianchi, A Berton, AL Serban, R Baldelli, LM Fatti, A Colao, M Arosio, for the Italian Study Group of Acromegaly

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Abstract

It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in acromegaly on a large series of acromegalic patients managed in the somatostatin analogs era. It was evaluated the incidence of cancer in an Italian nationwide multicenter cohort study of 1512 acromegalic patients, 624 men and 888 women, mean age at diagnosis 45 ± 13 years, followed up for a mean of 10 years (12573 person-years) in respect to the general Italian population. Cancer was diagnosed in 124 patients, 72 women and 52 men. The SIRs for all cancers was significantly increased compared to the general Italian population (expected: 88, SIR 1.41; 95% CI, 1.18-1.68, P 
Original languageEnglish
Pages (from-to)495-504
Number of pages10
JournalEndocrine-Related Cancer
Volume24
Issue number9
DOIs
Publication statusPublished - 2017

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Terzolo, M., Reimondo, G., Berchialla, P., Ferrante, E., Malchiodi, E., De Marinis, L., Pivonello, R., Grottoli, S., Losa, M., Cannavo, S., Ferone, D., Montini, M., Bondanelli, M., De Menis, E., Martini, C., Puxeddu, E., Velardo, A., Peri, A., Faustini-Fustini, M., ... Acromegaly, F. T. I. S. G. O. (2017). Acromegaly is associated with increased cancer risk: a survey in Italy. Endocrine-Related Cancer, 24(9), 495-504. https://doi.org/10.1530/ERC-16-0553