Abstract
In this study we have compared the effects of the ACTH 1-17 analogue, alsactide (Synchrodyn® 1-17,) and of the ACTH 1-24 fragment, on the dynamics of ACTH-cortisol secretion. In 2 healthy women, 100 μg alsactide injected i.m. at 0700 caused a much greater and sustained cortisol secretion than 100 μg ACTH 1-24. However, adrenocortical stimulation effected by alsactide terminated within 24 h, since plasma cortisol levels recorded 24 h after alsactide injection were even lower than the corresponding values of the previous day. In 8 other women, daily administration of 100 μg alsactide at 0700 for 15-days resulted in a significant blunting (p
Original language | English |
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Pages (from-to) | 159-165 |
Number of pages | 7 |
Journal | La Ricerca in Clinica e in Laboratorio |
Volume | 14 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 1984 |
Keywords
- ACTH 1-17
- ACTH 1-24
- ACTH analogues
- ACTH-related peptides
- Alsactide
- Hypothalamo-pituilary-adrenal axis
ASJC Scopus subject areas
- Clinical Biochemistry