ACTH 1-17 and pituitary-adrenal function in human

Francesco Cavagnini, Roldano Fossati

Research output: Contribution to journalArticle

Abstract

In this study we have compared the effects of the ACTH 1-17 analogue, alsactide (Synchrodyn® 1-17,) and of the ACTH 1-24 fragment, on the dynamics of ACTH-cortisol secretion. In 2 healthy women, 100 μg alsactide injected i.m. at 0700 caused a much greater and sustained cortisol secretion than 100 μg ACTH 1-24. However, adrenocortical stimulation effected by alsactide terminated within 24 h, since plasma cortisol levels recorded 24 h after alsactide injection were even lower than the corresponding values of the previous day. In 8 other women, daily administration of 100 μg alsactide at 0700 for 15-days resulted in a significant blunting (p

Original languageEnglish
Pages (from-to)159-165
Number of pages7
JournalLa Ricerca in Clinica e in Laboratorio
Volume14
Issue number2
DOIs
Publication statusPublished - Apr 1984

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Keywords

  • ACTH 1-17
  • ACTH 1-24
  • ACTH analogues
  • ACTH-related peptides
  • Alsactide
  • Hypothalamo-pituilary-adrenal axis

ASJC Scopus subject areas

  • Clinical Biochemistry

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