ACTH 1-17 and pituitary-adrenal function in human

Francesco Cavagnini; Roldano Fossati

doi:10.1007/BF02904968

ACTH 1-17 and pituitary-adrenal function in human

Francesco Cavagnini, Roldano Fossati

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

In this study we have compared the effects of the ACTH 1-17 analogue, alsactide (Synchrodyn^® 1-17,) and of the ACTH 1-24 fragment, on the dynamics of ACTH-cortisol secretion. In 2 healthy women, 100 μg alsactide injected i.m. at 07⁰⁰ caused a much greater and sustained cortisol secretion than 100 μg ACTH 1-24. However, adrenocortical stimulation effected by alsactide terminated within 24 h, since plasma cortisol levels recorded 24 h after alsactide injection were even lower than the corresponding values of the previous day. In 8 other women, daily administration of 100 μg alsactide at 07⁰⁰ for 15-days resulted in a significant blunting (p

Original language	English
Pages (from-to)	159-165
Number of pages	7
Journal	La Ricerca in Clinica e in Laboratorio
Volume	14
Issue number	2
DOIs	https://doi.org/10.1007/BF02904968
Publication status	Published - Apr 1984

Keywords

ACTH 1-17
ACTH 1-24
ACTH analogues
ACTH-related peptides
Alsactide
Hypothalamo-pituilary-adrenal axis

ASJC Scopus subject areas

Clinical Biochemistry

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10.1007/BF02904968

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abstract = "In this study we have compared the effects of the ACTH 1-17 analogue, alsactide (Synchrodyn{\textregistered} 1-17,) and of the ACTH 1-24 fragment, on the dynamics of ACTH-cortisol secretion. In 2 healthy women, 100 μg alsactide injected i.m. at 0700 caused a much greater and sustained cortisol secretion than 100 μg ACTH 1-24. However, adrenocortical stimulation effected by alsactide terminated within 24 h, since plasma cortisol levels recorded 24 h after alsactide injection were even lower than the corresponding values of the previous day. In 8 other women, daily administration of 100 μg alsactide at 0700 for 15-days resulted in a significant blunting (p",

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ACTH 1-17 and pituitary-adrenal function in human

Abstract

Keywords

ASJC Scopus subject areas

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