ACTH 1-17 effects in the chemotherapy of advanced solid tumors

Carlo Barone, Antonio Grieco, Antonio Astone, Loredana Vagliviello, Carlo Garufi, Aldo Virgilio Greco

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of administration of a synthetic ACTH analogue (ACTH 1-17, Synchrodyn®) in the chemotherapy of advanced-phase solid tumors was studied. In this preliminary report the following data are evaluated: response rate; occurrence of toxic effects; performance status of patients; several immunological parameters. The administration of Synchrodyn® seems mainly to influence the lymphocyte subpopulations and the occurrence of toxic effects. A final evaluation of the role that may be played by chronotherapy in the treatment of tumors must await further studies on the clinical response and tolerance.

Original languageEnglish
Pages (from-to)211-220
Number of pages10
JournalLa Ricerca in Clinica e in Laboratorio
Volume14
Issue number2
DOIs
Publication statusPublished - Apr 1984

Fingerprint

Chemotherapy
Tumors
Poisons
Drug Therapy
Chronotherapy
Cosyntropin
Neoplasms
Lymphocytes
Lymphocyte Subsets
ACTH (1-17)
Therapeutics

Keywords

  • ACTH
  • Chemotherapy
  • Chronotherapy
  • Immunocomplexes
  • Lymphacytes subpopulations

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Barone, C., Grieco, A., Astone, A., Vagliviello, L., Garufi, C., & Greco, A. V. (1984). ACTH 1-17 effects in the chemotherapy of advanced solid tumors. La Ricerca in Clinica e in Laboratorio, 14(2), 211-220. https://doi.org/10.1007/BF02904975

ACTH 1-17 effects in the chemotherapy of advanced solid tumors. / Barone, Carlo; Grieco, Antonio; Astone, Antonio; Vagliviello, Loredana; Garufi, Carlo; Greco, Aldo Virgilio.

In: La Ricerca in Clinica e in Laboratorio, Vol. 14, No. 2, 04.1984, p. 211-220.

Research output: Contribution to journalArticle

Barone, C, Grieco, A, Astone, A, Vagliviello, L, Garufi, C & Greco, AV 1984, 'ACTH 1-17 effects in the chemotherapy of advanced solid tumors', La Ricerca in Clinica e in Laboratorio, vol. 14, no. 2, pp. 211-220. https://doi.org/10.1007/BF02904975
Barone C, Grieco A, Astone A, Vagliviello L, Garufi C, Greco AV. ACTH 1-17 effects in the chemotherapy of advanced solid tumors. La Ricerca in Clinica e in Laboratorio. 1984 Apr;14(2):211-220. https://doi.org/10.1007/BF02904975
Barone, Carlo ; Grieco, Antonio ; Astone, Antonio ; Vagliviello, Loredana ; Garufi, Carlo ; Greco, Aldo Virgilio. / ACTH 1-17 effects in the chemotherapy of advanced solid tumors. In: La Ricerca in Clinica e in Laboratorio. 1984 ; Vol. 14, No. 2. pp. 211-220.
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