ACTH and cortisol secretion in patients with Alzheimer's disease

Massimo Franceschi, Lorena Airaghi, Cristina Gramigna, Giulio Truci, Maria Grazia Manfredi, Nicola Canal, Anna Catania

Research output: Contribution to journalArticlepeer-review


The "glucocorticoid cascade hypothesis" for pathological ageing of the brain is supported by strong experimental data, but the clinical correlates are far less clear. The basal ACTH and cortisol secretion have been studied before and after the dexamethasone suppression test in patients in the early stages of clinically probable Alzheimer's disease and in controls, and the results were all normal. These findings do not support the hypothesis that the pathological brain ageing of Alzheimer's type is caused by hyperactivity of the pituitaryadrenal axis.

Original languageEnglish
Pages (from-to)836-837
Number of pages2
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number9
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology


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